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Aquaporin-0 membrane junctions reveal the structure of a closed water pore
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1SOR
Primary Citation

Aquaporin-0 membrane junctions reveal the structure of a closed water pore.

Gonen, T.,  Sliz, P.,  Kistler, J.,  Cheng, Y.,  Walz, T.

Journal: (2004) Nature 429: 193-197

PubMed: 15141214  
DOI: 10.1038/nature02503  
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PubMed Abstract:
The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo. We show here that AQP0 from the lens core, containing some carboxy-terminally cleaved AQP0, forms double-layered crystals that recapitulate in vivo junctions. We... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Membrane Protein
    Structure Weight: 25173.60
    Molecule: Aquaporin-0
    Polymer: 1 Type: protein Length: 235
    Chains: A
    Organism Ovis aries
    Gene Names MIP AQP0
    UniProtKB:   Protein Feature View | Search PDB | Q6J8I9  
    Q6J8I9Molec. ProcessingLens fiber major intrinsic proteinMotifCyHelicalEHelicaliHeCHelicalExtrHelicalCytHeliiHeEHelicalCytoplasmicUP SitesUniProtKBSCOP domainsAquaporin-like Secstruc1SOR.APDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Ovis aries   Taxonomy   Common Name: Sheep  
     
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  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA,PQS (software)
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  •   Deposition Summary Hide
    Authors:   Gonen, T.,  Sliz, P.,  Kistler, J.,  Cheng, Y.,  Walz, T.

    Deposition:   2004-03-15
    Release:   2004-05-11
    Last Modified (REVDAT):   2011-07-13
     
  •   Revision History    Hide
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    2011-07-13
    Biological assembly
    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   ELECTRON CRYSTALLOGRAPHY
    Exp. Data:
      Structure Factors
    EDS  




    Space Group: P 4 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 65.50 α = 90.00 
    b = 65.50 β = 90.00 
    c = 160.00 γ = 90.00