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The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution
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1YMG
ENTRY 1YMG SUPERSEDES 1TM8
Primary Citation

The channel architecture of aquaporin 0 at a 2.2-A resolution.

Harries, W.E.C.,  Akhavan, D.,  Miercke, L.J.W.,  Khademi, S.,  Stroud, R.M.

Journal: (2004) Proc.Natl.Acad.Sci.USA 101: 14045-14050

PubMed: 15377788  
PubMedCentral: PMC521118  
DOI: 10.1073/pnas.0405274101  
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PubMed Abstract:
We determined the x-ray structure of bovine aquaporin 0 (AQP0) to a resolution of 2.2 A. The structure of this eukaryotic, integral membrane protein suggests that the selectivity of AQP0 for water transport is based on the identity and location... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Membrane Protein
    Structure Weight: 28857.90
    Molecule: Lens fiber major intrinsic protein
    Polymer: 1 Type: protein Length: 263
    Chains: A
    Organism Bos taurus
    Gene Name MIP
    UniProtKB:   Protein Feature View | Search PDB | P06624  
    P06624Molec. ProcessingLens fiber major intrinsic proteinMotifCyHelicalEHelicaliHeCHelicalExtrHelicalCytHeliiHeEHelicalCytoplasmicUP SitesUniProtKBSCOP domainsAquaporin-like PDB SitesSecstruc1YMG.APDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Bos taurus   Taxonomy   Common Name: Cattle  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    BNG
    Search 
    Download      		BNG C15 H30 O6
    B-NONYLGLUCOSIDE
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA,PQS (software)
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  •   Deposition Summary Hide
    Authors:   Harries, W.E.C.,  Akhavan, D.,  Miercke, L.J.W.,  Khademi, S.,  Stroud, R.M.

    Deposition:   2005-01-20
    Release:   2005-02-08
    Last Modified (REVDAT):   2012-06-20

    Previous versions:  1TM8
     
  •   Revision History    Hide
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    2012-06-20
    Function and keywords
    2012-05-09
    Function and keywords
    2011-07-13
    Version format compliance
    2011-07-13
    Biological assembly
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.24
    R-Value: 0.240 (obs.)
    R-Free: 0.303
    Space Group: P 4 21 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 110.53 α = 90.00 
    b = 110.53 β = 90.00 
    c = 53.39 γ = 90.00