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Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone
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2AMB
Primary Citation

Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.

Pereira de Jesus-Tran, K.,  Cote, P.-L.,  Cantin, L.,  Blanchet, J.,  Labrie, F.,  Breton, R.

Journal: (2006) Protein Sci. 15: 987-999

PubMed: 16641486  
PubMedCentral: PMC2242507  
DOI: 10.1110/ps.051905906  
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PubMed Abstract:
Androgens exert their effects by binding to the highly specific androgen receptor (AR). In addition to natural potent androgens, AR binds a variety of synthetic agonist or antagonist molecules with different affinities. To identify molecular determinants responsible for this selectivity,... [ Read More & Search PubMed Abstracts ]
 
 
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