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Crystal structure of human CYP11A1 in complex with 20-hydroxycholesterol
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3NA1
Primary Citation

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

Strushkevich, N.,  Mackenzie, F.,  Cherkesova, T.,  Grabovec, I.,  Usanov, S.,  Park, H.W.

Journal: (2011) Proc.Natl.Acad.Sci.USA 108: 10139-10143

PubMed: 21636783  
PubMedCentral: PMC3121847  
DOI: 10.1073/pnas.1019441108  
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PubMed Abstract:
In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin (Adx), and a cytochrome P450 (P450scc or CYP11A1). This complex not only plays a key role in steroidogenesis,... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Oxidoreductase , Electron Transport
    Structure Weight: 143137.74
    Molecule: Cholesterol side-chain cleavage enzyme, mitochondrial
    Polymer: 1 Type: protein Length: 487
    Chains: A, B
    EC#: 1.14.15.6   
    Fragment: UNP residues 41-521
    Organism Homo sapiens
    Gene Names CYP11A1 CYP11A
    UniProtKB:   Protein Feature View | Search PDB | P05108  
    P05108Molec. ProcessingMitochondrionCholesterol side-chain cleavage enzyme, mitochondrialE.C.1.14.15.6: Cholesterol monooxygenase (side-chain-cleaving)UP SitesUniProtKBPDB SitesSecstruc3NA1.A3NA1.BPDBTooltip
    Molecule: Adrenodoxin, mitochondrial
    Polymer: 2 Type: protein Length: 123
    Chains: C, D
    Fragment: UNP residues 62-184
    Organism Homo sapiens
    Gene Names FDX1 ADX
    UniProtKB:   Protein Feature View | Search PDB | P10109  
    P10109Molec. ProcessingMitochondrionAdrenodoxin, mitochondrialMotif2Fe-2S ferredoxin-typeUP SitesUniProtKBPDB SitesSecstruc3NA1.C3NA1.DPDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    3N9Y   
    3N9Z   
    3NA0   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    FES
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    Download      		FES Fe2 S2
    FE2/S2 (INORGANIC) CLUSTER
    HCD
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    Download      		HCD C27 H46 O2
    (3alpha,8alpha)-cholest-5-ene-3,20-diol
    HEM
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    Download      		HEM C34 H32 Fe N4 O4
    PROTOPORPHYRIN IX CONTAINING FE
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Biological assembly 1 assigned by authors
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