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Mineralocorticoid Receptor with Bound Aldosterone
2AA2
Primary Citation

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.

Bledsoe, R.K.,  Madauss, K.P.,  Holt, J.A.,  Apolito, C.J.,  Lambert, M.H.,  Pearce, K.H.,  Stanley, T.B.,  Stewart, E.L.,  Trump, R.P.,  Willson, T.M.,  Williams, S.P.

Journal: (2005) J.Biol.Chem. 280: 31283-31293

PubMed: 15967794  
DOI: 10.1074/jbc.M504098200  
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PubMed Abstract:
Ligand binding is the first step in hormone regulation of mineralocorticoid receptor (MR) activity. Here, we report multiple crystal structures of MR (NR3C2) bound to both agonist and antagonists. These structures combined with mutagenesis studies reveal that maximal receptor activation... [ Read More & Search PubMed Abstracts ]
 
 
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  Biological Assembly       
No symmetry
Stoichiometry: Monomer
Biological assembly 1 assigned by authors
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