Close-up view of MR-Progesterone hydrogen bond network. The 18-OH is positioned for hydrogen bonding (yellow dashed lines) with the Asn770 carbonyl, whereas the Asn770 amide remains in position for hydrogen bonding to the C-21 OH of Progesterone and Glu955, Ser767, which lies in the loop preceding the AF-2. Thr945, present on helix 9, forms a pair of hydrogen bonds with the C-20 and C-21 substituents of Progesterone. Cysteine 942 is in position to interact with the 18-OH group to give Progesterone Three potential hydrogen bonds to helix 9.
O-3 and water HOH26,5 is hydrogen-bonded Arg817, Ser810, Phe829, Gln776. Back to the tutorial