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STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
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2CBA
Primary Citation

Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.

Hakansson, K.,  Carlsson, M.,  Svensson, L.A.,  Liljas, A.

Journal: (1992) J.Mol.Biol. 227: 1192-1204

PubMed: 1433293  
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PubMed Abstract:
In order to obtain a better structural framework for understanding the catalytic mechanism of carbonic anhydrase, a number of inhibitor complexes of the enzyme were investigated crystallographically. The three-dimensional structure of free human carbonic anhydrase II was refined at pH... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Lyase(oxo Acid)
    Structure Weight: 29249.48
    Molecule: CARBONIC ANHYDRASE II
    Polymer: 1 Type: protein Length: 260
    Chains: A
    EC#: 4.2.1.1   
    Organism Homo sapiens
    Gene Name CA2
    UniProtKB:   Protein Feature View | Search PDB | P00918  
    P00918Molec. ProcessingCarbonic anhydrase 2MotifE.C.4.2.1.1: Carbonate dehydrataseUP SitesUniProtKBSCOP domainsCCarbonic anhydraseCarbonic anhydrase PDB SitesSecstruc2CBA.APDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    ZN
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    Download      		ZN Zn
    ZINC ION
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    ACE
    Search      		ACE C2 H4 O nonPolymer
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

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  •   Deposition Summary Hide
    Authors:   Hakansson, K.,  Carlsson, M.,  Svensson, L.A.,  Liljas, A.

    Deposition:   1992-06-01
    Release:   1993-10-31
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   1.54
    R-Value: 0.151 (obs.)
    R-Free: n/a
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 42.70 α = 90.00 
    b = 41.70 β = 104.60 
    c = 73.00 γ = 90.00