RCSB Protein Data Bank - RCSB PDB - 2VVA Structure Summary

HUMAN CARBONIC ANHYDRASE IN COMPLEX WITH CO2

DOI:10.2210/pdb2vva/pdb

2VVA

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Primary Citation

Structural study of X-ray induced activation of carbonic anhydrase.

Sjoblom, B., Polentarutti, M., Djinovic-Carugo, K.

Journal: (2009) Proc.Natl.Acad.Sci.USA 106: 10609-10613

PubMed: 19520834
PubMedCentral: PMC2705530
DOI: 10.1073/pnas.0904184106
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PubMed Abstract:

Carbonic anhydrase, a zinc metalloenzyme, catalyzes the reversible hydration of carbon dioxide to bicarbonate. It is involved in processes connected with acid-base homeostasis, respiration, and photosynthesis. More than 100 distinct human carbonic anhydrase II (HCAII) 3D structures have been generated... [ Read More & Search PubMed Abstracts ]

Molecular Description

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Polymer: 1

Scientific Name:

Homo sapiens

Taxonomy

Common Name:

Human

Expression System:

Escherichia coli

Related PDB Entries

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Identifier	Details
12CA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 121 REPLACED BY ALA (V121A)
1A42	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
1AM6	CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE
1AVN	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR
1BCD	CARBONIC ANHYDRASE II COMPLEX WITH TRIFLUOROMETHANE SULPHONAMIDE
1BIC	CARBONIC ANHYDRASE II MUTANT WITH THR 200 REPLACED BY HIS (T200H) COMPLEX WITH BICARBONATE
1BN1	CARBONIC ANHYDRASE II INHIBITOR
1BN3	CARBONIC ANHYDRASE II INHIBITOR
1BN4	CARBONIC ANHYDRASE II INHIBITOR
1BNM	CARBONIC ANHYDRASE II INHIBITOR
1BNN	CARBONIC ANHYDRASE II INHIBITOR
1BNQ	CARBONIC ANHYDRASE II INHIBITOR
1BNT	CARBONIC ANHYDRASE II INHIBITOR
1BNU	CARBONIC ANHYDRASE II INHIBITOR
1BNV	CARBONIC ANHYDRASE II INHIBITOR
1BNW	CARBONIC ANHYDRASE II INHIBITOR
1BV3	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA
1CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II)
1CA3	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (PH 5.7)
1CAH	CARBONIC ANHYDRASE II (NATIVE ZINC REPLACED BY COBALT) COMPLEX WITH BICARBONATE
1CAI	CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY ALA (E106A)
1CAJ	CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY ASP (E106D)
1CAK	CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY GLN (E106Q)
1CAL	CARBONIC ANHYDRASE II MUTANT WITH THR 199 REPLACED BY ALA (T199A)
1CAM	CARBONIC ANHYDRASE II MUTANT WITH THR 199 REPLACED BY ALA (T199A) COMPLEX WITH BICARBONATE
1CAN	CARBONIC ANHYDRASE II COMPLEX WITH NITRATE
1CAO	CARBONIC ANHYDRASE II COMPLEX WITH HYDROGEN SULFIDE
1CAY	CARBONIC ANHYDRASE II COMPLEX WITH ACETATE
1CAZ	CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY GLN (E106Q) COMPLEX WITH ACETATE
1CCS	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY ASP (T199D)
1CCT	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY GLU (T199E)
1CCU	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY HIS (T199H)
1CIL	CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR ETS
1CIM	CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR PTS
1CIN	CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR MTS
1CNB	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH HIS 94 REPLACED BY CYS (H94C) COMPLEXED WITH BETA-MERCAPTOETHANOL (BME)
1CNC	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH HIS 94 REPLACED BY CYS (H94C) COMPLEXED WITH ZINC
1CNG	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLU 117 REPLACED BY ALA (E117A)
1CNH	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY GLU (Q92E)
1CNI	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY ALA (Q92A)
1CNJ	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY ASN (Q92N)
1CNK	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY LEU (Q92L)
1CNW	MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: ETHYLAMINOCARBONYLBENZENESULFONAMIDE
1CNX	MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: BENZENESULFONAMIDE
1CNY	MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: AMINOCARBONYLBENZENESULFONAMIDE
1CRA	CARBONIC ANHYDRASE II COMPLEX WITH 1,2,4- TRIAZOLE
1CVA	CARBONIC ANHYDRASE II (HCA II) MUTANT WITH THR 199 REPLACED BY VAL (T199V) (AZIDE- BOUND FORM)
1CVB	CARBONIC ANHYDRASE II (HCA II) MUTANT WITH THR 199 REPLACED BY VAL (T199V) (SULFATE- BOUND FORM)
1CVC	CARBONIC ANHYDRASE II MUTANT WITH HIS 94 REPLACED BY ASP (H94D)
1CVD	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH HIS 119 REPLACED BY CYS (H119C)
1CVE	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH HIS 119 REPLACED BY ASP (H119D)
1CVF	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH HIS 94 REPLACED BY ALA (H94A)
1CVH	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE II, HCA II) MUTANT WITH HIS 96 REPLACED BY CYS (H96C)
1DCA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH THR 199 REPLACED BY CYS (T199C)
1DCB	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH THR 199 REPLACED BY CYS (T199C)
1EOU	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXEDWITH AN ANTICONVULSANT SUGAR SULFAMATE
1F2W	THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
1FQL	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M /W97V CARBONICANHYDRASE (CAII) VARIANT
1FQM	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I /F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT
1FQN	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I /F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT
1FQR	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT
1FR4	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT
1FR7	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S /F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT
1FSN	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S /F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT
1FSQ	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT
1FSR	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT
1G0E	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMANCARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE
1G0F	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMANCARBONIC ANHYDRASE II
1G1D	CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]- BENZAMIDE
1G3Z	CARBONIC ANHYDRASE II (F131V)
1G45	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]- BENZAMIDE
1G46	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL) METHYL]-BENZAMIDE
1G48	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL) METHYL]-BENZAMIDE
1G4J	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6- PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
1G4O	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE
1G52	CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL ]-BENZAMIDE
1G53	CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL ]-BENZAMIDE
1G54	CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,3,4,5,6- PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
1H4N	H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS
1H9N	H119N CARBONIC ANHYDRASE II
1H9Q	H119Q CARBONIC ANHYDRASE II
1HCA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (PH 6.5)
1HEA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY ARG (L198R)
1HEB	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY GLU (L198E)
1HEC	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY HIS (L198H)
1HED	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY ALA (L198A)
1HVA	CARBONIC ANHYDRASE II MUTANT WITH HIS 94 REPLACED BY CYS (H94C)
1I8Z	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4- MORPHOLINYL)-, 1,1-DIOXIDE
1I90	CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-, 1,1-DIOXIDE, (R)
1I91	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4- MORPHOLINYL)-, 1,1-DIOXIDE
1I9L	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]- BENZAMIDE
1I9M	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL) METHYL]-BENZAMIDE
1I9N	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL) METHYL]-BENZAMIDE
1I9O	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL )METHYL]-BENZAMIDE
1I9P	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL )METHYL]-BENZAMIDE
1I9Q	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL )METHYL]-BENZAMIDE
1IF4	CARBONIC ANHYDRASE II COMPLEXED WITH 4- FLUOROBENZENESULFONAMIDE
1IF5	CARBONIC ANHYDRASE II COMPLEXED WITH 2,6- DIFLUOROBENZENESULFONAMIDE
1IF6	CARBONIC ANHYDRASE II COMPLEXED WITH 3,5- DIFLUOROBENZENESULFONAMIDE
1IF7	CARBONIC ANHYDRASE II COMPLEXED WITH (R)-N -(3-INDOL-1-YL-2-METHYL-PROPYL)-4- SULFAMOYL-BENZAMIDE
1IF8	CARBONIC ANHYDRASE II COMPLEXED WITH (S)-N -(3-INDOL-1-YL-2-METHYL-PROPYL)-4- SULFAMOYL-BENZAMIDE
1IF9	CARBONIC ANHYDRASE II COMPLEXED WITH N-[2-( 1H-INDOL-5-YL)-BUTYL]-4-SULFAMOYL- BENZAMIDE
1KWQ	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07
1KWR	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36
1LG5	CRYSTAL STRUCTURE ANALYSIS OF THE HCA II MUTANT T199P INCOMPLEX WITH BETA- MERCAPTOETHANOL
1LG6	CRYSTAL STRUCTURE ANALYSIS OF HCA II MUTANT T199P INCOMPLEX WITH THIOCYANATE
1LGD	CRYSTAL STRUCTURE ANALYSIS OF HCA II MUTANT T199P INCOMPLEX WITH BICARBONATE
1LUG	FULL MATRIX ERROR ANALYSIS OF CARBONIC ANHYDRASE
1LZV	SITE-SPECIFIC MUTANT (TYR7 REPLACED WITH HIS ) OF HUMANCARBONIC ANHYDRASE II
1MOO	SITE SPECIFIC MUTANT (H64A) OF HUMAN CARBONIC ANHYDRASE IIAT HIGH RESOLUTION
1MUA	CARBONIC ANHYDRASE II MUTANT WITH PRO 202 REPLACED BY ALA (P202A)
1OKL	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1- SULFONAMIDE
1OKM	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)] BENZAMIDE
1OKN	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5- FLUORESCEIN THIOUREA)BUTANE)]
1OQ5	CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR
1RAY	CARBONIC ANHYDRASE II COMPLEX WITH AZIDE
1RAZ	CARBONIC ANHYDRASE II COMPLEX WITH BROMIDE
1RZA	CARBONIC ANHYDRASE II WITH ZINC REPLACED BY COBALT(II)
1RZB	CARBONIC ANHYDRASE II WITH ZINC REPLACED BY BY COBALT(II) AT PH 6.0
1RZC	CARBONIC ANHYDRASE II WITH ZINC REPLACED BY COPPER(II)
1RZD	CARBONIC ANHYDRASE II WITH ZINC REPLACED BY MANGANESE(II)
1RZE	CARBONIC ANHYDRASE II WITH ZINC REPLACED BY NICKEL(II)
1T9N	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TB0	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TBT	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TE3	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TEQ	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TEU	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TG3	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TG9	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TH9	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1THK	EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II
1TTM	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 667-COUMATE
1UGA	HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
1UGB	HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY GLY (A65G)
1UGC	HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY HIS (A65H)
1UGD	HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY SER (A65S)
1UGE	HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
1UGF	HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY THR (A65T)
1UGG	HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY SER (A65S) - ORTHORHOMBIC FORM
1XEG	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXEDWITH AN ACETATE ION
1XEV	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN A NEWCRYSTAL FORM
1YDA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY GLU (L198E) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE
1YDB	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY PHE (L198F) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE
1YDC	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY PHE (L198F)
1YDD	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE
1YO0	PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
1YO1	PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
1YO2	PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
1Z9Y	CARBONIC ANHYDRASE II IN COMPLEX WITH FUROSEMIDE ASSULFONAMIDE INHIBITOR
1ZE8	CARBONIC ANHYDRASE II IN COMPLEX WITH A MEMBRANE-IMPERMEANTSULFONAMIDE INHIBITOR
1ZFK	CARBONIC ANHYDRASE II IN COMPLEX WITH N-4 -SULFONAMIDPHENYL-N'-4-METHYLBENZOSULFONYLUREASE AS SULFONAMIDE INHIBITOR
1ZFQ	CARBONIC ANHYDRASE II IN COMPLEX WITH ETHOXZOLAMIDPHENOLEAS SULFONAMIDE INHIBITOR
1ZGE	CARBONIC ANHYDRASE II IN COMPLEX WITH P- SULFONAMIDO-O,O'-DICHLOROANILINE AS SULFONAMIDE INHIBITOR
1ZGF	CARBONIC ANHYDRASE II IN COMPLEX WITH TRICHLOROMETHIAZIDEAS SULFONAMIDE INHIBITOR
1ZH9	CARBONIC ANHYDRASE II IN COMPLEX WITH N-4 -METHYL-1-PIPERAZINYL-N'-(P-SULFONAMIDE) PHENYLTHIOUREA ASSULFONAMIDE INHIBITOR
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
2ABE	CARBONIC ANHYDRASE ACTIVATORS: X-RAY CRYSTAL STRUCTURE OFTHE ADDUCT OF HUMAN ISOZYME II WITH L-HISTIDINE AS APLATFORM FOR THE DESIGN OF STRONGER ACTIVATORS
2AW1	CARBONIC ANHYDRASE INHIBITORS: VALDECOXIB BINDS TO ADIFFERENT ACTIVE SITE REGION OF THE HUMAN ISOFORM II ASCOMPARED TO THE STRUCTURALLY RELATED CYCLOOXYGENASE II"SELECTIVE " INHIBITOR CELECOXIB
2AX2	PRODUCTION AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF FULLYDEUTERATED HUMAN CARBONIC ANHYDRASE II
2CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) COMPLEX WITH THIOCYANATE ION
2CBA	CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, PH 7.8)
2CBB	CARBONIC ANHYDRASE II (80 MM SODIUM CITRATE , 2.4 M AMMONIUM SULFATE, PH 6.0)
2CBC	CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, 0.2 FORMATE, PH 7.6)
2CBD	CARBONIC ANHYDRASE II (2.4 M AMMONIUM SULFATE, 0.3 M SODIUM BISULFITE, PH 7.3 )
2CBE	CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, 2MM DIPICOLINATE, PH 7.8)
2EU2	HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
2EU3	HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
2EZ7	CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOZYMES I, II,IV, VA, VII AND XIV WITH L- AND D-HISTIDINE ANDCRYSTALLOGRAPHIC ANALYSIS OF THEIR ADDUCTS WITH ISOFORMII: ENGINEERING PROTON TRANSFER PROCESSES WITHIN THEACTIVE SITE OF AN ENZYME
2FMG	CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II,IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE ANDCRYSTALLOGRAPHIC ANALYSIS OF THEIR ADDUCTS WITH ISOZYMEII: STEROSPECIFIC RECOGNITION WITHIN THE ACTIVE SITE OF ANENZYME AND ITS CONSEQUENCES FOR THE DRUG DESIGN, STRUCTUREWITH L-PHENYLALANINE
2FMZ	CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II,IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE,STRUCTURE WITH D- PHENYLALANINE.
2FOQ	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS
2FOS	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS
2FOU	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS
2FOV	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS
2GEH	N-HYDROXYUREA, A VERSATILE ZINC BINDING FUNCTION IN THEDESIGN OF METALLOENZYME INHIBITORS
2H4N	H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
2HD6	CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II INCOMPLEX WITH A HYPOXIA- ACTIVATABLE SULFONAMIDE.
2VVB	HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BICARBONATE
3CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) COMPLEX WITH 3-MERCURI-4- AMINOBENZENESULFONAMIDE (AMS).
4CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II)
4CAC	CARBONIC ANHYDRASE FORM C (PH 6)
5CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (MUTANT WITH THR 200 REPLACED WITH SER) (T200S)
5CAC	CARBONIC ANHYDRASE FORM C COMPLEX WITH HYDROGEN SULFITE
6CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH PHE (V143F)
7CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH GLY (V143G)
8CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH HIS (V143H)
9CA2	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH TYR (V143Y)

Ligand Chemical Component

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Identifier	Formula	Name	Interactions
CO2 Search Download	C O₂	CARBON DIOXIDE		Ligand Explorer
GOL Search Download	C₃ H₈ O₃	GLYCEROL		Ligand Explorer
SO4 Search Download	O₄ S	SULFATE ION		Ligand Explorer
ZN Search Download	Zn	ZINC ION		Ligand Explorer

External Ligand Annotations

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Identifier

Binding Affinity (Sequence Identity %)

Ki:	>200 nM (100)	- data from BindingDB
N/A	in BindingMoad
N/A	in PDBbind

External Domain Annotations Hide
CATH Classification v3.4.0: 1 Domain - data from CATH

Pfam Classification: 1 Domain - data from Pfam

GO Terms: 34 Terms - data from GO
Structural Biology Knowledgebase Data Hide
Information from the Structural Biology Knowledgebase
Related Biological Annotations: >21 annotations
Related Clones from PSI:Biology Materials Repository: 0 clones
Related Targets & Protocols from TargetTrack: 0 targets

Data in orange boxes are gathered from external resources (when available).

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Biological Assembly

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Biological assembly 1 assigned by authors and generated by PQS (software)

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Deposition Summary

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Authors: Sjoeblom, B., Polentarutti, M., Djinovic-Carugo, K.

Deposition:	2008-06-04
Release:	2009-07-14

Revision History Hide

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2011-07-13
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Experimental Details

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Method: X-RAY DIFFRACTION
Exp. Data:
Structure Factors
EDS

Unit Cell:
	Length [Å]	Angles [°]
	a = 42.59	α = 90.00
	b = 41.58	β = 104.84
	c = 72.64	γ = 90.00

Molecule of the Month Hide
Carbonic Anhydrase