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Human carbonic anhydrase II in complex with bicarbonate
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2VVB
Primary Citation

Structural study of X-ray induced activation of carbonic anhydrase.

Sjoblom, B.,  Polentarutti, M.,  Djinovic-Carugo, K.

Journal: (2009) Proc.Natl.Acad.Sci.USA 106: 10609

PubMed: 19520834  
PubMedCentral: PMC2705530  
DOI: 10.1073/pnas.0904184106  
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PubMed Abstract:
Carbonic anhydrase, a zinc metalloenzyme, catalyzes the reversible hydration of carbon dioxide to bicarbonate. It is involved in processes connected with acid-base homeostasis, respiration, and photosynthesis. More than 100 distinct human carbonic anhydrase II (HCAII) 3D structures have been generated... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Lyase
    Structure Weight: 29836.01
    Molecule: CARBONIC ANHYDRASE 2
    Polymer: 1 Type: protein Length: 260
    Chains: X
    EC#: 4.2.1.1   
    Organism Homo sapiens
    Gene Name CA2
    UniProtKB:   Protein Feature View | Search PDB | P00918  
    P00918Molec. ProcessingCarbonic anhydrase 2MotifE.C.4.2.1.1: Carbonate dehydrataseUP SitesUniProtKBSCOP domainsCCarbonic anhydraseCarbonic anhydrase PDB SitesSecstruc2VVB.XPDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    12CA  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 121 REPLACED BY ALA (V121A) 
    1A42  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE 
    1AM6  CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE 
    1AVN  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR 
    1BCD  CARBONIC ANHYDRASE II COMPLEX WITH TRIFLUOROMETHANE SULPHONAMIDE 
    1BIC  CARBONIC ANHYDRASE II MUTANT WITH THR 200 REPLACED BY HIS (T200H) COMPLEX WITH BICARBONATE 
    1BN1  CARBONIC ANHYDRASE II INHIBITOR 
    1BN3  CARBONIC ANHYDRASE II INHIBITOR 
    1BN4  CARBONIC ANHYDRASE II INHIBITOR 
    1BNM  CARBONIC ANHYDRASE II INHIBITOR 
    1BNN  CARBONIC ANHYDRASE II INHIBITOR 
    1BNQ  CARBONIC ANHYDRASE II INHIBITOR 
    1BNT  CARBONIC ANHYDRASE II INHIBITOR 
    1BNU  CARBONIC ANHYDRASE II INHIBITOR 
    1BNV  CARBONIC ANHYDRASE II INHIBITOR 
    1BNW  CARBONIC ANHYDRASE II INHIBITOR 
    1BV3  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA 
    1CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) 
    1CA3  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (PH 5.7) 
    1CAH  CARBONIC ANHYDRASE II (NATIVE ZINC REPLACED BY COBALT) COMPLEX WITH BICARBONATE 
    1CAI  CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY ALA (E106A) 
    1CAJ  CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY ASP (E106D) 
    1CAK  CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY GLN (E106Q) 
    1CAL  CARBONIC ANHYDRASE II MUTANT WITH THR 199 REPLACED BY ALA (T199A) 
    1CAM  CARBONIC ANHYDRASE II MUTANT WITH THR 199 REPLACED BY ALA (T199A) COMPLEX WITH BICARBONATE 
    1CAN  CARBONIC ANHYDRASE II COMPLEX WITH NITRATE 
    1CAO  CARBONIC ANHYDRASE II COMPLEX WITH HYDROGEN SULFIDE 
    1CAY  CARBONIC ANHYDRASE II COMPLEX WITH ACETATE 
    1CAZ  CARBONIC ANHYDRASE II MUTANT WITH GLU 106 REPLACED BY GLN (E106Q) COMPLEX WITH ACETATE 
    1CCS  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY ASP (T199D) 
    1CCT  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY GLU (T199E) 
    1CCU  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH THR 199 REPLACED BY HIS (T199H) 
    1CIL  CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR ETS 
    1CIM  CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR PTS 
    1CIN  CARBONIC ANHYDRASE II COMPLEXED WITH THE INHIBITOR MTS 
    1CNB  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH HIS 94 REPLACED BY CYS (H94C) COMPLEXED WITH BETA-MERCAPTOETHANOL (BME) 
    1CNC  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II) MUTANT WITH HIS 94 REPLACED BY CYS (H94C) COMPLEXED WITH ZINC 
    1CNG  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLU 117 REPLACED BY ALA (E117A) 
    1CNH  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY GLU (Q92E) 
    1CNI  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY ALA (Q92A) 
    1CNJ  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY ASN (Q92N) 
    1CNK  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE, HCA II, CA2) MUTANT WITH GLN 92 REPLACED BY LEU (Q92L) 
    1CNW  MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: ETHYLAMINOCARBONYLBENZENESULFONAMIDE 
    1CNX  MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: BENZENESULFONAMIDE 
    1CNY  MOL_ID: 1; MOLECULE: CARBONIC ANHYDRASE II; CHAIN: NULL; SYNONYM: CARBONATE DEHYDRATASE, HCA II; EC: 4.2.1.1; HETEROGEN: AMINOCARBONYLBENZENESULFONAMIDE 
    1CRA  CARBONIC ANHYDRASE II COMPLEX WITH 1,2,4- TRIAZOLE 
    1CVA  CARBONIC ANHYDRASE II (HCA II) MUTANT WITH THR 199 REPLACED BY VAL (T199V) (AZIDE- BOUND FORM) 
    1CVB  CARBONIC ANHYDRASE II (HCA II) MUTANT WITH THR 199 REPLACED BY VAL (T199V) (SULFATE- BOUND FORM) 
    1CVC  CARBONIC ANHYDRASE II MUTANT WITH HIS 94 REPLACED BY ASP (H94D) 
    1CVD  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH HIS 119 REPLACED BY CYS (H119C) 
    1CVE  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH HIS 119 REPLACED BY ASP (H119D) 
    1CVF  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH HIS 94 REPLACED BY ALA (H94A) 
    1CVH  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE II, HCA II) MUTANT WITH HIS 96 REPLACED BY CYS (H96C) 
    1DCA  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH THR 199 REPLACED BY CYS (T199C) 
    1DCB  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH THR 199 REPLACED BY CYS (T199C) 
    1EOU  CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXEDWITH AN ANTICONVULSANT SUGAR SULFAMATE 
    1F2W  THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION 
    1FQL  X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M /W97V CARBONICANHYDRASE (CAII) VARIANT 
    1FQM  X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I /F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT 
    1FQN  X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I /F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT 
    1FQR  X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT 
    1FR4  X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97VCARBONIC ANHYDRASE (CAII) VARIANT 
    1FR7  X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S /F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT 
    1FSN  X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S /F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT 
    1FSQ  X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT 
    1FSR  X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97MCARBONIC ANHYDRASE (CAII) VARIANT 
    1G0E  SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMANCARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE 
    1G0F  SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMANCARBONIC ANHYDRASE II 
    1G1D  CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]- BENZAMIDE 
    1G3Z  CARBONIC ANHYDRASE II (F131V) 
    1G45  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]- BENZAMIDE 
    1G46  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL) METHYL]-BENZAMIDE 
    1G48  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL) METHYL]-BENZAMIDE 
    1G4J  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6- PENTAFLUOROPHENYL)METHYL]-BENZAMIDE 
    1G4O  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE 
    1G52  CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL ]-BENZAMIDE 
    1G53  CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL ]-BENZAMIDE 
    1G54  CARBONIC ANHYDRASE II COMPLEXED WITH 4-( AMINOSULFONYL)-N-[(2,3,4,5,6- PENTAFLUOROPHENYL)METHYL]-BENZAMIDE 
    1H4N  H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS 
    1H9N  H119N CARBONIC ANHYDRASE II 
    1H9Q  H119Q CARBONIC ANHYDRASE II 
    1HCA  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (PH 6.5) 
    1HEA  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) 
    1HEB  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY GLU (L198E) 
    1HEC  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY HIS (L198H) 
    1HED  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH LEU 198 REPLACED BY ALA (L198A) 
    1HVA  CARBONIC ANHYDRASE II MUTANT WITH HIS 94 REPLACED BY CYS (H94C) 
    1I8Z  CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4- MORPHOLINYL)-, 1,1-DIOXIDE 
    1I90  CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-, 1,1-DIOXIDE, (R) 
    1I91  CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6- SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4- MORPHOLINYL)-, 1,1-DIOXIDE 
    1I9L  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]- BENZAMIDE 
    1I9M  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL) METHYL]-BENZAMIDE 
    1I9N  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL) METHYL]-BENZAMIDE 
    1I9O  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL )METHYL]-BENZAMIDE 
    1I9P  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL )METHYL]-BENZAMIDE 
    1I9Q  CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL )METHYL]-BENZAMIDE 
    1IF4  CARBONIC ANHYDRASE II COMPLEXED WITH 4- FLUOROBENZENESULFONAMIDE 
    1IF5  CARBONIC ANHYDRASE II COMPLEXED WITH 2,6- DIFLUOROBENZENESULFONAMIDE 
    1IF6  CARBONIC ANHYDRASE II COMPLEXED WITH 3,5- DIFLUOROBENZENESULFONAMIDE 
    1IF7  CARBONIC ANHYDRASE II COMPLEXED WITH (R)-N -(3-INDOL-1-YL-2-METHYL-PROPYL)-4- SULFAMOYL-BENZAMIDE 
    1IF8  CARBONIC ANHYDRASE II COMPLEXED WITH (S)-N -(3-INDOL-1-YL-2-METHYL-PROPYL)-4- SULFAMOYL-BENZAMIDE 
    1IF9  CARBONIC ANHYDRASE II COMPLEXED WITH N-[2-( 1H-INDOL-5-YL)-BUTYL]-4-SULFAMOYL- BENZAMIDE 
    1KWQ  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07 
    1KWR  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36 
    1LG5  CRYSTAL STRUCTURE ANALYSIS OF THE HCA II MUTANT T199P INCOMPLEX WITH BETA- MERCAPTOETHANOL 
    1LG6  CRYSTAL STRUCTURE ANALYSIS OF HCA II MUTANT T199P INCOMPLEX WITH THIOCYANATE 
    1LGD  CRYSTAL STRUCTURE ANALYSIS OF HCA II MUTANT T199P INCOMPLEX WITH BICARBONATE 
    1LUG  FULL MATRIX ERROR ANALYSIS OF CARBONIC ANHYDRASE 
    1LZV  SITE-SPECIFIC MUTANT (TYR7 REPLACED WITH HIS ) OF HUMANCARBONIC ANHYDRASE II 
    1MOO  SITE SPECIFIC MUTANT (H64A) OF HUMAN CARBONIC ANHYDRASE IIAT HIGH RESOLUTION 
    1MUA  CARBONIC ANHYDRASE II MUTANT WITH PRO 202 REPLACED BY ALA (P202A) 
    1OKL  CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1- SULFONAMIDE 
    1OKM  CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)] BENZAMIDE 
    1OKN  CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5- FLUORESCEIN THIOUREA)BUTANE)] 
    1OQ5  CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR 
    1RAY  CARBONIC ANHYDRASE II COMPLEX WITH AZIDE 
    1RAZ  CARBONIC ANHYDRASE II COMPLEX WITH BROMIDE 
    1RZA  CARBONIC ANHYDRASE II WITH ZINC REPLACED BY COBALT(II) 
    1RZB  CARBONIC ANHYDRASE II WITH ZINC REPLACED BY BY COBALT(II) AT PH 6.0 
    1RZC  CARBONIC ANHYDRASE II WITH ZINC REPLACED BY COPPER(II) 
    1RZD  CARBONIC ANHYDRASE II WITH ZINC REPLACED BY MANGANESE(II) 
    1RZE  CARBONIC ANHYDRASE II WITH ZINC REPLACED BY NICKEL(II) 
    1T9N  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TB0  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TBT  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TE3  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TEQ  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TEU  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TG3  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TG9  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TH9  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1THK  EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+TRANSFER IN HUMAN CARBONIC ANHYDRASE II 
    1TTM  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 667-COUMATE 
    1UGA  HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY PHE (A65F) 
    1UGB  HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY GLY (A65G) 
    1UGC  HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY HIS (A65H) 
    1UGD  HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY SER (A65S) 
    1UGE  HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY LEU (A65L) 
    1UGF  HUMAN CARBONIC ANHYDRASE II [HCAII] MUTANT WITH ALA 65 REPLACED BY THR (A65T) 
    1UGG  HUMAN CARBONIC ANHYDRASE II[HCAII] MUTANT WITH ALA 65 REPLACED BY SER (A65S) - ORTHORHOMBIC FORM 
    1XEG  CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXEDWITH AN ACETATE ION 
    1XEV  CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN A NEWCRYSTAL FORM 
    1YDA  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY GLU (L198E) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE 
    1YDB  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY PHE (L198F) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE 
    1YDC  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY PHE (L198F) 
    1YDD  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE)( HCA II) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) COMPLEXED WITH TRANSITION STATE ANALOG ACETAZOLAMIDE 
    1YO0  PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II 
    1YO1  PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II 
    1YO2  PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II 
    1Z9Y  CARBONIC ANHYDRASE II IN COMPLEX WITH FUROSEMIDE ASSULFONAMIDE INHIBITOR 
    1ZE8  CARBONIC ANHYDRASE II IN COMPLEX WITH A MEMBRANE-IMPERMEANTSULFONAMIDE INHIBITOR 
    1ZFK  CARBONIC ANHYDRASE II IN COMPLEX WITH N-4 -SULFONAMIDPHENYL-N'-4-METHYLBENZOSULFONYLUREASE AS SULFONAMIDE INHIBITOR 
    1ZFQ  CARBONIC ANHYDRASE II IN COMPLEX WITH ETHOXZOLAMIDPHENOLEAS SULFONAMIDE INHIBITOR 
    1ZGE  CARBONIC ANHYDRASE II IN COMPLEX WITH P- SULFONAMIDO-O,O'-DICHLOROANILINE AS SULFONAMIDE INHIBITOR 
    1ZGF  CARBONIC ANHYDRASE II IN COMPLEX WITH TRICHLOROMETHIAZIDEAS SULFONAMIDE INHIBITOR 
    1ZH9  CARBONIC ANHYDRASE II IN COMPLEX WITH N-4 -METHYL-1-PIPERAZINYL-N'-(P-SULFONAMIDE) PHENYLTHIOUREA ASSULFONAMIDE INHIBITOR 
    1ZSA  CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 
    1ZSB  CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE 
    1ZSC  CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 
    2ABE  CARBONIC ANHYDRASE ACTIVATORS: X-RAY CRYSTAL STRUCTURE OFTHE ADDUCT OF HUMAN ISOZYME II WITH L-HISTIDINE AS APLATFORM FOR THE DESIGN OF STRONGER ACTIVATORS 
    2AW1  CARBONIC ANHYDRASE INHIBITORS: VALDECOXIB BINDS TO ADIFFERENT ACTIVE SITE REGION OF THE HUMAN ISOFORM II ASCOMPARED TO THE STRUCTURALLY RELATED CYCLOOXYGENASE II"SELECTIVE " INHIBITOR CELECOXIB 
    2AX2  PRODUCTION AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF FULLYDEUTERATED HUMAN CARBONIC ANHYDRASE II 
    2CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) COMPLEX WITH THIOCYANATE ION 
    2CBA  CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, PH 7.8) 
    2CBB  CARBONIC ANHYDRASE II (80 MM SODIUM CITRATE , 2.4 M AMMONIUM SULFATE, PH 6.0) 
    2CBC  CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, 0.2 FORMATE, PH 7.6) 
    2CBD  CARBONIC ANHYDRASE II (2.4 M AMMONIUM SULFATE, 0.3 M SODIUM BISULFITE, PH 7.3 ) 
    2CBE  CARBONIC ANHYDRASE II (50 MM TRIS, 3 M AMMONIUM SULFATE, 2MM DIPICOLINATE, PH 7.8) 
    2EU2  HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS 
    2EU3  HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS 
    2EZ7  CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOZYMES I, II,IV, VA, VII AND XIV WITH L- AND D-HISTIDINE ANDCRYSTALLOGRAPHIC ANALYSIS OF THEIR ADDUCTS WITH ISOFORMII: ENGINEERING PROTON TRANSFER PROCESSES WITHIN THEACTIVE SITE OF AN ENZYME 
    2FMG  CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II,IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE ANDCRYSTALLOGRAPHIC ANALYSIS OF THEIR ADDUCTS WITH ISOZYMEII: STEROSPECIFIC RECOGNITION WITHIN THE ACTIVE SITE OF ANENZYME AND ITS CONSEQUENCES FOR THE DRUG DESIGN, STRUCTUREWITH L-PHENYLALANINE 
    2FMZ  CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II,IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE,STRUCTURE WITH D- PHENYLALANINE. 
    2FOQ  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS 
    2FOS  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS 
    2FOU  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS 
    2FOV  HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONGINHIBITORS 
    2GEH  N-HYDROXYUREA, A VERSATILE ZINC BINDING FUNCTION IN THEDESIGN OF METALLOENZYME INHIBITORS 
    2H4N  H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE 
    2HD6  CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II INCOMPLEX WITH A HYPOXIA- ACTIVATABLE SULFONAMIDE. 
    2VVA  HUMAN CARBONIC ANHYDRASE IN COMPLEX WITH CO2 
    3CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) COMPLEX WITH 3-MERCURI-4- AMINOBENZENESULFONAMIDE (AMS). 
    4CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) 
    4CAC  CARBONIC ANHYDRASE FORM C (PH 6) 
    5CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (MUTANT WITH THR 200 REPLACED WITH SER) (T200S) 
    5CAC  CARBONIC ANHYDRASE FORM C COMPLEX WITH HYDROGEN SULFITE 
    6CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH PHE (V143F) 
    7CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH GLY (V143G) 
    8CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH HIS (V143H) 
    9CA2  CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) MUTANT WITH VAL 143 REPLACED WITH TYR (V143Y) 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    BCT
    Search 
    Download      		BCT C H O3
    BICARBONATE ION
    CO2
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    Download      		CO2 C O2
    CARBON DIOXIDE
    GOL
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    Download      		GOL C3 H8 O3
    GLYCEROL
    SO4
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    Download      		SO4 O4 S
    SULFATE ION
    ZN
    Search 
    Download      		ZN Zn
    ZINC ION
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    BCT
    Search 
    Download      		BCT
    Ki: 73000000 - 85000000 nM (100) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
    SO4
    Search 
    Download      		SO4
    Ki: >200 nM (100) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   MyPDB Personal Annotations Hide

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  •   Deposition Summary Hide
    Authors:   Sjoeblom, B.,  Polentarutti, M.,  Djinovic-Carugo, K.

    Deposition:   2008-06-04
    Release:   2009-07-14
    Last Modified (REVDAT):   2012-08-22
     
  •   Revision History    Hide
    Mouse over text for details
    2012-08-22
    Non-polymer description
    2012-08-22
    Other
    2012-08-22
    Geometry validation
    2012-08-22
    Citation
    2012-08-22
    Biological assembly
    2012-08-22
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   1.66
    R-Value: 0.171 (obs.)
    R-Free: 0.213
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 42.67 α = 90.00 
    b = 41.65 β = 104.79 
    c = 72.91 γ = 90.00