Lecture 13: Glycolysis and the Citric Acid Cycle

 Bookeeping

Topic

Reading

 
  • Metabolism
    • catabolism(oxidation)/Anabolism(reduction)
 

 Net Yield

per Glucose


2 ATP

2 NADH

  • Glycolysis
    • glucose to pyruvate in cytoplasm
    • Byproducts of glycolysis
      • ATP/ADP
        • up the glycolysis hill - utilize 2 ATP hydrolysis energy
        • down the energy hill - produce 4 ATP
      • NADH/NAD+
        • down energy hill - produce 2 NADH

 pages 169-179

 2 CO2

2 NADH

  • Transition Step
    • Pyruvate to AcetylCoA transfer from cytoplasm to mitochondria
    • First 2 carbons from glucose lost as carbon dioxide
    • Produce 2 NADH
    • Product shuttled into matrix of mitochondria
 

 4 CO2

3 NADH

1 FADH2

1 ATP

  • Citric Acid Cycle
    • AcetylCoA coupled to C4(oxaloacetate) to yield C6(citric acid)
    • Through 2 steps remaining carbons lost as CO2 completing glucose to 6 CO2
    • Each cycle yields 3 NADH, 1 FADH2 and 1 GTP that is immediately converted to ATP
    • Cycle ends with regeneration of C4 oxaloacetate.
 


return to schedule