Mutations in GroES

NOTE: Residue numbering includes N-terminal Met. Mutations are listed in sequence order

Mutation

Effect

Reference

G23DUnable to support lambda & T5 phage plaque
formation as single copy

(2)

G24DUnable to support lambda & T5 phage plaque
formation as single copy; decreased growth at 42

(2)

A31VUnable to support lambda phage plaque
formation as single copy

(2)

K34AIncreased cooperativity of ATP hydrolysis by GroEL

(1)

K34EIncreased cooperativity of ATP hydrolysis by GroEL

(1)

This information is accurate to the best of my knowledge. However, you should check the references cited for a more complete understanding of these mutations and their effects.

References

  1. Kovalenko et al (1994) Biochemistry 34: 14974-14978.
  2. Landry et al (1993) Nature 364: 255-258.

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