Spacefilling model.
Heavy Chain,
Light Chain,
Lysozyme Antigen
Backbone.
Disulfide bonds.
The variable fragment, Fv,
is the minimal antigen-binding fragment.
CDR's of Fv (side view).
L1
L2
L3
H3
H2
H1
Non-epitope Light,
Heavy.
CDR's Identified (facing paratope).
Paratope contact atoms (within 4.2 Å of epitope).
Lysozyme Contact Atoms superimposed over the paratope on Fv.
Lysozyme's backbone
is shown with the epitope portions thickened. The epitope is
discontinuous
(N--->C)
and
flat.
CDR's:Epitope.
CDR's.
Epitope.