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HUMAN SERUM ALBUMIN COMPLEXED WITH WARFARIN
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2BXD
Primary Citation

Structural basis of the drug-binding specificity of human serum albumin.

Ghuman, J.,  Zunszain, P.A.,  Petitpas, I.,  Bhattacharya, A.A.,  Otagiri, M.,  Curry, S.

Journal: (2005) J.Mol.Biol. 353: 38

PubMed: 16169013  
DOI: 10.1016/j.jmb.2005.07.075  
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PubMed Abstract:
Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations. The problem of overcoming the binding affinity of lead compounds for HSA represents a major challenge in... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Transport Protein
    Structure Weight: 133760.26
    Molecule: SERUM ALBUMIN
    Polymer: 1 Type: protein Length: 585
    Chains: A, B
    Organism Homo sapiens
    UniProtKB:   Protein Feature View | Search PDB | P02768  
    P02768UniProtKBPDB SitesPDBTooltip
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Pichia pastoris  
     
  •   Related PDB Entries Hide
    Identifier Details
    1AO6  CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN 
    1BJ5  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID 
    1BKE  HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID 
    1BM0  CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN 
    1E78  CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN 
    1E7A  CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC PROPOFOL 
    1E7B  CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH HALOTHANE 
    1E7C  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID AND THE GENERAL ANESTHETIC HALOTHANE 
    1E7E  HUMAN SERUM ALBUMIN COMPLEXED WITH DECANOIC ACID 
    1E7F  HUMAN SERUM ALBUMIN COMPLEXED WITH DODECANOIC ACID 
    1E7G  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID 
    1E7H  HUMAN SERUM ALBUMIN COMPLEXED WITH HEXADECANOIC ACID 
    1E7I  HUMAN SERUM ALBUMIN COMPLEXED WITH OCTADECANOIC ACID 
    1GNI  HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-9- OCTADECENOIC ACID (OLEIC ACID) 
    1GNJ  HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8 ,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID) 
    1H9Z  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID AND THE R-(+) ENANTIOMER OF WARFARIN 
    1HA2  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID AND THE S-(-) ENANTIOMER OF WARFARIN 
    1HK1  HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) 
    1HK2  HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L- THYRONINE) 
    1HK3  HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L- THYRONINE) 
    1HK4  HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) AND MYRISTIC ACID (TETRADECANOIC ACID) 
    1HK5  HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L- THYRONINE) AND MYRISTIC ACID (TETRADECANOIC ACID) 
    1N5U  X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME 
    1O9X  HUMAN SERUM ALBUMIN COMPLEXED WITH TETRADECANOIC ACID (MYRISTIC ACID) AND HEMIN 
    1TF0  CRYSTAL STRUCTURE OF THE GA MODULE COMPLEXED WITH HUMANSERUM ALBUMIN 
    1UOR  X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN 
    1YSX  SOLUTION STRUCTURE OF DOMAIN 3 FROM HUMAN SERUM ALBUMINCOMPLEXED TO AN ANTI-APOPTOTIC LIGAND DIRECTED AGAINST BCL-XL AND BCL-2 
    2BX8  HUMAN SERUM ALBUMIN COMPLEXED WITH AZAPROPAZONE 
    2BXA  HUMAN SERUM ALBUMIN COMPLEXED WITH 3-CARBOXY -4-METHYL-5-PROPYL-2-FURANPROPANOIC ACID (CMPF) 
    2BXB  HUMAN SERUM ALBUMIN COMPLEXED WITH OXYPHENBUTAZONE 
    2BXC  HUMAN SERUM ALBUMIN COMPLEXED WITH PHENYLBUTAZONE 
    2BXE  HUMAN SERUM ALBUMIN COMPLEXED WITH DIFLUNISAL 
    2BXF  HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM 
    2BXG  HUMAN SERUM ALBUMIN COMPLEXED WITH IBUPROFEN 
    2BXH  HUMAN SERUM ALBUMIN COMPLEXED WITH INDOXYL SULFATE 
    2BXI  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND AZAPROPAZONE 
    2BXK  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, AZAPROPAZONE AND INDOMETHACIN 
    2BXL  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND 3,5-DIIODOSALICYLIC ACID 
    2BXM  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND INDOMETHACIN 
    2BXN  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND IODIPAMIDE 
    2BXO  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND OXYPHENBUTAZONE 
    2BXP  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND PHENYLBUTAZONE 
    2BXQ  HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, PHENYLBUTAZONE AND INDOMETHACIN 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    RWF
    Search 
    Download      		RWF C19 H16 O4
    R-WARFARIN
    		RWF:2BXD
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PQS (software)
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