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X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
3HS6
Primary Citation

Structural basis of fatty acid substrate binding to cyclooxygenase-2.

Vecchio, A.J.,  Simmons, D.M.,  Malkowski, M.G.

Journal: (2010) J.Biol.Chem. 285: 22152-22163

PubMed: 20463020  
PubMedCentral: PMC2903402  
DOI: 10.1074/jbc.M110.119867  
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PubMed Abstract:
The cyclooxygenases (COX-1 and COX-2) are membrane-associated heme-containing homodimers that generate prostaglandin H(2) from arachidonic acid (AA). Although AA is the preferred substrate, other fatty acids are oxygenated by these enzymes with varying efficiencies. We determined the crystal structures of... [ Read More & Search PubMed Abstracts ]
 
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Symmetry: C2 view
Stoichiometry: Homo 2-mer - A2
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Vecchio, A.J.,  Simmons, D.M.,  Malkowski, M.G.

    Deposition:   2009-06-10
    Release:   2010-05-12
    Last Modified (REVDAT):   2010-08-04
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.40
    R-Value: 0.179 (obs.)
    R-Free: 0.223
    Space Group: I 2 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 121.85 α = 90.00 
    b = 132.34 β = 90.00 
    c = 180.29 γ = 90.00