Human microsomal cytochrome P450 2b6 (CYP2b6) heme with bound(+)-alpha-pinene on iron(III) moiety. The axial ligand at the fifth coordination site of the heme iron(III) is provided by the sulfide S- of Cys439 in 2b6. Coordination of the heme iron by ionic donor acceptor bond Fe3+-S- plays a central role in singlet oxygen bonding scission at the sixth coordination site on the heme iron(III). Back to the tutorial.

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he four pyrol rings of the porphyrine are serrounding by nitrogen atoms the central irone(III).
The four methyl groups -CH3 and two vinyl groups >C= -CH2 support hydrophobic accommodation of heme interior.
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