C3S CSO CHOLEST-5-EN-3-YL HYDROGEN SULFATE CHOLESTEROL-SULFATE By converting cholesterol to 24S-hydroxycholesterol, cytochrome P450 46A1 (CYP46A1) initiates the pathway step for removal from the brain at cholesterol homeostasis metabolism.. The axial ligand at the fifth coordination site of the heme iron(III) is provided by the sulfide S- of Cys437 in 46a1. Coordination of the heme iron by ionic donor acceptor bond Fe3+-S- plays a central role in singlet oxygen bonding scission at the sixth coordination site on the heme iron(III). Back to the tutorial.

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The four pyrol rings of the porphyrine are serrounding by nitrogen atoms the central irone(III).
The four methyl groups -CH3 and two vinyl groups >C= -CH2 support hydrophobic accommodation of heme interior and active saite substrate .
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