Model of human IgG
	human IgG1 model L-H=H-L (Fab)2 ----------- Fc Fc Receptor binding region carbohydrate

References:

This model of human IgG1 was created by combining Brookhaven X-ray coordinate files for the antibody Fc ( 1fc2.pdb ) and F(ab') ( 2ig2.pdb ) fragments, where the latter coordinates were symmetrically rotated to generate the bivalent F(ab')₂ arms ( bio2ig2.pdb ).

1. E. A. Padlan . "Anatomy of the Antibody Molecule." Molecular Immunology31:169 (1994).

The binding site on IgG1 for FcgRI was deduced by mutational studies:

1. A. R. Duncan, J. M. Woof, L.J. Partridge, D. R. Burton, & G. Winter. "Localization of the binding site for the human high-affinity Fc receptor on IgG." Nature332:563 (1988).
2. S. M. Canfield & S. L. Morrison. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the C_H2 domain and is modulated by the hinge region." Journal of Experimental Medicine173:1483 (1991).

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© Duane W. Sears
Revised: August 07, 1998