After reading this chapter you should be able to:
- Describe the mechanism of oxygen binding to myoglobin and hemoglobin.
- Describe conformational differences between deoxygenated and oxygenated hemoglobins.
- Define the concept of cooperativity in oxygen binding to hemoglobin.
- Describe the Bohr effect and its role in modulating the binding of oxygen to hemoglobin.
- Explain how 2,3-bisphosphoglycerate interacts with hemoglobin and influences oxygen binding.
- Summarize the processes by which carbon dioxide is transported from peripheral tissues to the lungs.
- Describe the major classifications of hemoglobinopathies.
- Describe the molecular basis of sickle cell disease.
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