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5 Catalytic Proteins-Enzymes
Body_ID: C00533410
J Fujii
Body_ID: ctrb94
LEARNING OBJECTIVES
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After reading this chapter you should be able to:
  • Describe the characteristics of enzymatic reactions from the viewpoint of free energy, equilibrium, kinetics and direction of the reactions in comparison with simple chemical reactions.
  • Discuss the structure and composition of enzymes, including cofactors, and conditions that affect enzymatic reactions.
  • Describe enzyme kinetics based on the Michaelis-Menten equation and the significance of the Michaelis constant (Km).
  • Describe the elements of enzyme structure that explain their substrate specificity and catalytic activity.
  • Describe regulatory mechanisms affecting enzymatic reactions, including regulation by allosteric effectors and covalent modification.
  • Differentiate among the three types of enzyme inhibition from the viewpoint of enzyme kinetics.
  • Discuss the therapeutic use of enzyme inhibitors and the diagnostic utility of clinical enzyme assays.
Body_ID: P005001
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