| 17 Lipids and Lipoproteins
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After reading this chapter you should be able to:
- Describe the composition and functions of different lipoproteins present in plasma: chylomicrons, very-low-density lipoproteins, remnant particles, low-density lipoproteins and high-density lipoproteins.
- Describe the fuel transport pathway and the overflow pathway of lipoprotein metabolism.
- Describe the reverse cholesterol transport and its links with other pathways.
- Outline mechanisms and regulation of intracellular cholesterol levels, including the role of relevant genes, transcription factors, and receptor and enzyme proteins.
- Comment on laboratory tests used to assess lipid metabolism and the cardiovascular risk of a person.
- Comment on the relationships between the main component processes of atherogenesis: endothelial dysfunction, arterial deposition of lipids, inflammatory phenomena and their relation to plaque growth and rupture.
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