| 29 Biosynthesis and Degradation of Nucleotides
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After reading this chapter you should be able to:
- Compare and contrast the structure and biosynthesis of purines and pyrimidines, highlighting the differences between de novo and salvage pathways.
- Describe how cells meet their requirements for nucleotides at various stages in their cell cycle, at rest and during cell division.
- Describe the metabolic basis and therapy for classic disorders in nucleotide metabolism: Lesch-Nyhan syndrome, gout and SCIDS.
- Explain the biochemical rationale for using methotrexate in chemotherapy.
- Describe several metabolic conditions that result in accumulation of orotic acid in urine.
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