| 30 Deoxyribonucleic acid (DNA)
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After reading this chapter you should be able to:
- Describe the composition and structure of DNA, based on the Watson-Crick model, including the concepts of directionality and complementarity in DNA structure.
- Outline the process for packaging of DNA in the nucleus.
- Explain how replication of DNA is achieved with high fidelity in a bidirectional manner and in a semi-conservative fashion.
- Discuss the enzymes involved, the activities at replication forks, and the structures and intermediates participating in the replication process.
- Describe the mechanism by which replication is controlled in the eukaryotic cell.
- Describe the nature of the damage and mechanisms involved in the repair of damage to DNA.
- Explain the mechanism of action of AZT for treatment of AIDS.
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