After reading this chapter you should be able to:
- Describe the relationship between aging and disease.
- Explain the Gompertz plot and how it describes the rate of aging of different species.
- Differentiate between biological and chemical theories of aging.
- Explain the precepts of the free radical theory of aging, including identification of characteristic oxidation products that accumulate in long-lived proteins with age.
- Outline the evidence that the rate of mutation of DNA is an important determinant of the rate of aging.
- Explain the evidence in support of mitochondrial theories of aging and describe how this theory interfaces with the free radical theory of aging.
- Describe the etiology and pathology characteristic of several diseases of accelerated aging.
- Describe the effects of caloric restriction on the rate of aging of rodents.
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