Home > 25 Complex Carbohydrates: Glycoproteins > OTHER PATHWAYS OF SUGAR NUCLEOTIDE METABOLISM > Guanosine diphosphate-mannose

Guanosine diphosphate-mannose Body_ID: HC025017 GDP-Man is not only the mannose donor for glycoprotein synthesis, but it is also the precursor of l-fucose, a deoxyhexose that is an important recognition signal in many glycoproteins and glycolipids. The conversion of GDP-d-Man to GDP-l-fucose involves a complex series of oxidative and reductive steps, as well as epimerizations. Failure of this pathway causes leukocyte adhesion deficiency disease (LAD). Body_ID: P025027 page 365 Copyright © 2007 Elsevier Inc. All rights reserved. Read our Terms and Conditions of Use and our Privacy Policy. For problems or suggestions concerning this service, please contact: studentconsult.help@elsevier.com