STUDENT CONSULT (ver. 2.3)

Summary

Body_ID: HC027033

The ECM contains a complex array of fibrillar and network-forming collagens, elastin fibers, a stiff gelatinous matrix of proteoglycans, and a number of glycoproteins that mediate the interaction of these molecules with one another and with the cell surface. These molecules and their interactions afford structure, stability, and elasticity to the ECM, and provide a route for communication between the intra- and extra-cellular environments in tissues. The heterogeneity of both the protein and the carbohydrate components of these molecules provides for the great diversity in the structure and function of the ECM in various tissues.

Body_ID: P027041

ACTIVE LEARNING

Body_ID: B027006

Compare the structure of heparin, its mechanism of action, its route and frequency of administration to that of other common anticoagulants, such as aspirin and coumarin derivatives.
Discuss factors that promote the turnover of ECM components, as part of normal growth and development and in diseases, such as rheumatoid arthritis.
Review the consequences of genetic defects in sulfation of proteoglycans.

Body_ID: PB27010

Further reading

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Hulmes DJ. Building collagen molecules, fibrils, and suprafibrillar structures. J Struct Biol 2002;137(1-2):2-10. Full article Go to this article on the publisher's site

Go to this article on the publisher's site

Body_ID: R027001

Aumailley M, Gayraud B. Structure and biological activity of the extracellular matrix. J Mol Med 1998;76:253-265. Full article Go to this article on the publisher's site

Body_ID: R027002

Myllyharju J, Kivirikko KI. Collagens and collagen-related diseases. Ann Med 2001;33(1):7-21.

Body_ID: R027003

Brown JC, Timpl R. The collagen superfamily. Int Arch Allergy Immunol 1995;107:484-490.

Body_ID: R027004

Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. J Pathol 2003;200(4):423-428. Full article Go to this article on the publisher's site

Body_ID: R027005

Clark EA, Bruggse JS. Integrins and signal transduction pathways: the road taken. Science 1995;268:233-239.

Body_ID: R027006

Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Int Med 1997;242:27-33. Full article Go to this article on the publisher's site

Body_ID: R027007

Mewer UM, Engvall E. Domains of laminin. J Cell Biochem 1996;61:493-501.

Body_ID: R027008

Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases and potentials for

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therapy. Annu Rev Biochem 1995;64:403-434.

Body_ID: R027010

Rosenbloom J, Abrams WR, Mecham R. Extracellular matrix 4: the elastic fiber. FASEB J 1993;7:1208-1218.

Body_ID: R027011

Timpl R, Brown JC. Supramolecular assembly of basement membranes. Bioessays 1996;18:123-132.

Body_ID: R027012

Tilstra DJ, Byers PH. Molecular basis of hereditary disorders of connective tissue. Annu Rev Med 1994;45:149-163. Full article Go to this article on the publisher's site

Body_ID: R027013

Relevant websites

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Ehrlers-Danlos syndrome: http://www.nlm.nih.gov/medlineplus/ehlersdanlossyndrome.html Open this link in a new window