Ethanol oxidation reaction by alcohol dehydrogenase (ADH) (EC 1.1.1.1) enzyme in catalytic domain with nicotinamide adenine dinucleotide NAD⁺ oxidized form NAD⁺ and zinc(2+) ion coordinated alcohol group and His51 hydrogen bond linked water molecule.
H₃C-CH₂-OH+NAD⁺+H₂OH₃C-HC=O+NADH+H₃O⁺


hydride H^- ion tuneling in one attempt to form reduced form NADH in second instant process jump of proton H⁺ to water molecule H₂O coordinated by zinc(2+) ion to form hydroxonium ion H₃O⁺.
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