Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
complexed with Steroid Lipid HCD
(3alpha,8alpha)-cholest-5-ene-3,20-diol

Aris Kaksis     Riga Stradin's University 2014

I. Cholesterol derivative
(3alpha,8alpha)-cholest-5-ene-3,20-diol


Cholester3,20diol
Atoms constitute Cholesterol: Oxygen O red Carbons C gray, Hydrogen H white. Poorely soluble in water due to hydroxyl group -OH.
Spacefill model
Show two Oxygen O red atoms
Carbon atom cycle-Ring A
Carbon atom cycle-Ring B
Carbon atom cycle-Ring C
Carbon atom cycle-Ring D
All atoms C27 H46 O labels colored CPK shown
Labels O, C, H, relative to atoms
All atoms C27 H46 O colored CPK labels of
Off light dark
brighten on
London-Dispersion Forces (Wan Der Walls) Surface on Surface off
Background black Background white Background green

Cholesterol is the Metabolic Key Lipid Molecule for Steroide Hormones and Bile Acids
Cholester3,20diol Storage Form and Sorce of Steroids in Human Body.
Substrate Enzyme:3NA1Marz =>Steroid Hormone pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Enzyme: P450scc CYP11A1
EC 1.14.15.6
Protein DATA BANK file RCSB
PNAS June 21, 2011 vol. 108 no. 25
Substrate Enzyme: 3N9ZMarz =>Steroid Hormone pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Enzyme: P450scc CYP11A1
EC 1.14.15.6
Protein DATA BANK file RCSB
References
1. PNAS June 21, 2011 vol. 108 no. 25 
based on Eric Marz (1997) Membrane. Massachusetts University USA.
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