Rabbit cytochrome P450 2B4 in complex with the inhibitor AMLODIPINE
C20 H25 CL N2 O5. Rabbit cytochrome P450 2B4 in complex with molecules of the calcium channel blocker amlodipine inhibitors, in A and B conformation 180° for chlorbenzene ClC₆H₄-HEMEOAXAB to iron(III) moiety the active-site cavity. The axial ligand at the fifth coordination site of the heme iron(III) is provided by the sulfide S^- of Cys436 in 2a6. Coordination of the heme iron by ionic donor acceptor bond Fe³⁺-S^- plays a central role in singlet oxygen bonding scission at the sixth coordination site on the heme iron(III). Back to the tutorial.

Transfere Grafic File 3tmz2b4HemAmlodipinACys436.tgf and 3tmz2b4HemAmlodipinBCys436.tgfIntegrated Scientific Information System deposit DATA:

The four pyrol rings of the porphyrine are serrounding by nitrogen atoms the central irone(III).
The four methyl groups -CH₃ and two vinyl groups >C= -CH₂ support hydrophobic accommodation of heme interior and active saite substrate .
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