Bivalent Noninteractive Ligand Binding (lig)
An example of bivalent ligand bindingis modeled by examining the acid-base titration properties ofg glycine. Fully protonated -- "saturated" -- glycine undergoes a two-step dissociation reaction with decreasing hydronium ion concentration. Fully deprotonated -- "desaturated" -- glycine undergoes a two-step association reaction with increasing hydronium ion concentration.
Continue the acid-base titration analysis of glycine with an Excel spreadsheet where the first worksheet ("Sat Plots") shows two saturation plots -- one with Ya, the association fraction, plotted against pH and the other with Ya plotted directly against [H+] on a log scale.
Glycine Acid-Base Titration
Bivalent (Noninteractive) Ligand Binding
"Quit" Excel before moving to the next exercise.
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|©|| Duane W. Sears |
Revised: August 10, 1998