| 13 The Tricarboxylic Acid Cycle
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After reading this chapter you should be able to:
- Outline the sequence of reactions in the tricarboxylic acid (TCA) cycle and explain the purpose of the cycle.
- Identify the four oxidative enzymes in the TCA cycle and their products.
- Identify the two intermediates required in the first step of the TCA cycle and their metabolic sources.
- Identify four major metabolic intermediates synthesized from TCA cycle intermediates.
- Describe how the TCA cycle is regulated by substrate supply, allosteric effectors, covalent modification, and protein synthesis.
- Explain why there is no net synthesis of glucose
 from acetyl-CoA. - Explain the concept of 'suicide substrate' as applied to the TCA cycle.
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