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Summary
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  • Vitamins function mostly as cofactors to enzymes.
  • Fat soluble vitamins can be stored in the adipose tissue but there usually is only a short-term supply of the water-soluble ones.
  • Dietary micronutrient deficiencies are most likely to occur in susceptible groups with increased demand, or in people unable to maintain sufficient intake. Children, pregnant women, the elderly and low-income groups are particularly vulnerable.
  • Gastrointestinal disease and gastrointestinal surgery are potential causes of micronutrient deficiencies.
  • Vitamin and trace metal supplements are particularly important in patients who remain on artificial diets and on parenteral nutrition.
  • While there are controversies regarding some vitamin supplementation, the intake of fruit and vegetables as sources of micronutrients is unequivocally recommended.
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ACTIVE LEARNING
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  1. Compare and contrast the deficiencies of vitamin B12 and folic acidView drug information.
  2. When may an increased intake of a nutrient or energy precipitate vitamin deficiencies?
  3. Is vitamin AView drug information supplementation safe?
  4. Describe the clinical importance of copper.
  5. Which vitamins play a role in the development of hyperhomocysteinemia?
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Further reading
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Dietary reference values for food energy and nutrients for the United Kingdom. Report of the Panel on Dietary reference Values of the Committee on Medical aspects of Food Policy. London,TSO, 2003. Full articleGo to this article on the publisher's site
Body_ID: R010001
Colquhoun DM. Nutraceuticals: vitamins and other nutrients in coronary heart disease. Current Opinion Lipidol 2001;12:639-46. Full articleGo to this article on the publisher's site
Body_ID: R010002
Asplund K. Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review. J Int Med 2002;251:372-92. Full articleGo to this article on the publisher's site
Body_ID: R010003
Fairfield, KM, Fletcher, RH. Vitamins for chronic disease prevention in adults: Scientific review. JAMA 2002;287:3116-26. Full articleGo to this article on the publisher's site
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Fletcher RH. Fairfield KM. Vitamins for chronic disease prevention in adults: Clinical applications. JAMA 2002;287:3127-29. Full articleGo to this article on the publisher's site
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Brown BG. Cheung MC,Lee, A C, Zhao Xue-Qiao, Chait A. Antioxidant vitamins and lipid therapy: End of a long romance? Arteriosclerosis, Thrombosis & Vascular Biology 2002;22:1535-46. Full articleGo to this article on the publisher's site
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Jones, G. Eating fruit and vegetables. BMJ 2003;326:888.
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Websites
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US Preventive Services Task Force www.preventiveservices.ahrq.gov
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National Guideline Clearinghouse www.guideline.gov)
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