| Turnover of phospholipids
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| Phospholipids are in a continuous state of turnover in most membranes. This occurs as a result of oxidative damage, during inflammation, and through activation of lipases, particularly in response to hormonal stimuli. As shown in Figure 26.8, there are number of phospholipases that act on specific bonds in the phospholipid structure. Phospholipases A2 (PLA2) and C (PLC) are particularly active during the inflammatory response and in signal transduction. Phospholipase B (not shown) is a lysophospholipase that removes the second acyl group after action of PLA1 or PLA2. The lysophospholipids and other products are recycled by scavenger pathways.
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