Home > 30 Deoxyribonucleic acid > THE CELL CYCLE > Summary

Summary Body_ID: HC030031 page 435 page 436 Body_ID: P0436 The genome is composed of DNA, an antiparallel, double-stranded helical polymer of deoxyribonucleotides, stabilized by hydrogen binding between complementary bases. The DNA is packaged in the chromosome in a highly organized, condensed structure. Genetic information is replicated by a semi-conservative mechanism in which the parental strands are separated and both act as templates for daughter DNA. The replication of DNA is a complex, stringently regulated process. DNA is the only polymer in the body that is repaired, rather than degraded, following chemical or biological modification. Repair mechanisms generally involve excision of modified bases and replacement, using the unmodified strand as a template. Body_ID: P030050 ACTIVE LEARNING Body_ID: B030008 What are the possible functions of unusual forms of DNA? Discuss the possible roles for middle repetitive and highly repetitive sequences in DNA. Fragile X syndrome is the most common form of inherited mental retardation in humans. What is the role of non-genomic DNA in the pathogenesis of this disease? Hereditary nonpolyposis colon cancer results from a defect in DNA mismatch repair. Why is this condition autosomal dominant? Body_ID: PB30019 Further reading Body_ID: None Ahmed A, Tollefsbol T. Telomeres and telomerase: basic science implications for aging. J Am Geriatr Soc 2001;49:1105-1109. Full article Body_ID: R030001 Cleaver JE, Crowley E. UV damage, DNA repair and skin carcinogenesis. Front Biosci 2002;7:d1024-d1043. Body_ID: R030002 Norgauer J, Idzko M, Panther E, Hellstern O, Herouy Y. Xeroderma Pigmentosum. Eur J Dermatol 2003;13:4-9. Body_ID: R030003 Sekiguchi M, Tsuzuki T. Oxidative nucleotide damage: consequences and prevention. Oncogene 2002;21:8895-8904. Full article Body_ID: R030004 Venter JC, et al. (2001) The sequence of the human genome. Science 2001;291:1304-1351. Full article Body_ID: R030005 Watson JD. A passion for DNA. Genes, genomes and society. (Oxford University Press: Oxford, 2000) 250pp. Full article Body_ID: R030006 Watson JD. The double helix: a personal account of the discovery of the structure of DNA. (Norton: New York, 1980) 298pp. Full article Body_ID: R030007 Wilson III D, Sofinowski T, McNeill D. Repair mechanisms for oxidative DNA damage. Front Biosci 2003;8:963-981. Body_ID: R030008 Zannis-Hadjopoulos M, Price GB. Eukaryotic DNA replication. J Cell Biochem Suppl 1999;32/33:1-14. Full article Body_ID: R030009 Relevant websites Body_ID: None DNA workshop: www.pbs.org/wgbh/aso/tryit/dna Full article Body_ID: R030010 Genetic diseases: www.rarediseases.org Full article Body_ID: R030011 Graphics: www.accessexcellence.org/AB/GG/structure.html Full article Body_ID: R030012 Human Genome Project: www.ornl.gov/TechResources/Human_Genome/ Full article Body_ID: R030013 General educational: www.dnaftb.org; www.dnalc.org; www.dnai.org; www.accessexcellence.org/AB/GG/ Full article Body_ID: R030014 DNA repair: http://dir.niehs.nih.gov/dirlmg/DNArepair.html Full article Body_ID: R030015 DNA replication: http://dir.niehs.nih.gov/dirlmg/repl.html Full article Body_ID: R030016 Mitochondrial DNA: www.mitomap.org Full article Body_ID: R030017 DNA organization and nucleosomes: http://medweb4.bham.ac.uk/jspdf/m102pdf/DNA1.pdf Full article Body_ID: R030018 http://medweb4.bham.ac.uk/jspdf/m102pdf/DNA2.pdf Full article Body_ID: R030019 Body_ID: P0437 pages 435 - 436 Copyright © 2007 Elsevier Inc. All rights reserved. Read our Terms and Conditions of Use and our Privacy Policy. For problems or suggestions concerning this service, please contact: studentconsult.help@elsevier.com