Duane Sears at UCSB Biochemistry Computer Lab Web Site
MCDB 108AL

Professor Duane W. Sears

Professor of Immunology and Biochemistry

Department of Molecular, Cellular, and Developmental Biology

University of California Santa Barbara

BIOGRAPHICAL SKETCH
Antibody Human IgG1
Lymphotoxin Lymphotoxin-a

Professor Sears joined the faculty at the University of California Santa Barbara in 1977 following completion of his postdoctoral studies on the biochemistry of murine MHC antigens at Albert Einstein College of Medicine. Prior to that, he earned his Ph.D. in Biophysical Chemistry at Columbia University, analyzing the kinetics of immunoglobulin heavy and light chain assembly, a project which sparked his interest in immunology. His work and teaching at UCSB are both underscored by a fundamental desire to understand the structure-function relationships of proteins, as reflected in the Kuby web site and the instructional web sites created for his courses. The unifying theme of his research at UCSB has been the analysis of immunological cell-killing mechanisms.

[animated GIF]
IgG MODEL
[312 x 239 pixels; 62898 bytes]
Binding site on human IgG1 for FcgRI.
Lymphotoxin-a (LT-a)
(or TNF-
b
, center)
+
1, 2, and/or 3 TNF-R1chains
(outside)

See two animated views of this complex

[Green residues are membrane proximal.]


1tnr.pdb

Duane W. Sears
Professor of Immunology and Biochemistry
Department of Molecular, Cellular, & Developmental Biology
Interdepartmental Program in Biochemistry and Molecular Biology
University of California Santa Barbara
Santa Barbara, CA 93106

Footnotes:

  1. S. S. Burnside, P. Hunt, K. Ozato, and D. W. Sears. "A Molecular Hybrid of the H-2Dd and H-2Ld Genes Expressed in the dm1 Mutant." Proc. Natl. Acad. Sci. USA 81:5204 (1984).
  2. J. E. Christiaansen and D. W. Sears. "Unusually Efficient Tumor Cell Lysis by Human Effectors of Antibody-Dependent Cellular Cytotoxicity Mediated by Monoclonal Antibodies." Cancer Res. 44:3712 (1984).
  3. D. L. Farber, R. Giorda, M. Y. Nettleton, M. Trucco, J. P. Kochan, and D. W. Sears. "Rat Class III Fcg Receptor Isoforms Differ in IgG Subclass-Binding Specificity and Fail to Associate Productively with Rat CD3z." J. Immunol. 150:4364 (1993).
  4. D. W. Sears, N. Osman, B. Tate, I. F. C. McKenzie, and P. M. Hogarth. "Molecular Cloning and Expression of the Mouse High Affinity Fc Receptor for IgG." J. Immunol.144::371 (1990).

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Duane W. Sears
September 25, 1998