Ch. 4 Hb 4A2 BPG Binding Site

2,3 BPG Binding Pocket of deoxyHbA

Instructions: If not already visible in the lower frame, load the X-ray structures for deoxyHbA and oxyHbA . Compare different portions of the structures of deoxy- and oxyHbA by clicking the buttons below and maneuvering the resulting images with the mouse. Also, click on deoxyHb or oxyHb to view enlarged images of these structures.
1. Spacefilled images of HbA looking down between the two b-subunits (dark and light red) into the region of the 2,3-BPG binding pocket of deoxyHb Note that this pocket is deeper and more open in the deoxyHb conformer.
deoxyHbA BPG pocket & b-b interface	closed oxyHbA BPG pocket & b-b interface

Color Scheme

2. Closeup of the region of the 2,3-BPG binding pocket between the two b-subunits (dark and light red).
dexoxyHbA BPG pocket (open) labeled labels off	oxyHbA BPG pocket (closed) labeled labels off

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