Ch. 4 Hb 4A5B HbF BPG Binding Site

Comparison between the 2,3 BPG Binding Pockets of HbA and HbF

Instructions: Click here to bring the " HbA & HbF " web page into view in the bottom frame. The left image shows the structure of deoxyHbA and the right image shows the structure of deoxyHbF.
1. Wireframe images of human adult hemoglobin, deoxyHbA and deoxyHbF with the heme groups spacefilled.
deoxyHbA spacefilled heme on off	deoxyHbF spacefilled heme on off

2. Spacefilled images looking down between the two b -subunits of HbA or two g-subunits of HbF (dark and light red) into the region of the 2,3-BPG binding pocket.
deoxyHbA BPG pocket & b-b interface	deoxyHbF BPG pocket & g-g interface
Color Scheme

3. Closeup of the region of the 2,3-BPG binding pocket between the two b-subunits of deoxyHbA or the two g-subunits of deoxyHbF (dark and light red).
deoxyHbA labeled BPG pocket (open) labels off	deoxyHbF labeled BPG pocket (closed) labels off

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