Ch. 4 Hb 4A1 Spacefilled Hb

Hemoglobin Spacefilled

Instructions: If not already visible in the lower frame, load the X-ray structures for deoxyHbA and oxyHbA. Compare different portions of the structures of deoxy- and oxyHbA by clicking the buttons below and maneuvering the resulting images with the mouse. Also, click on deoxyHb or oxyHb to view enlarged images of these structures.
1. Wireframe images of human adult hemoglobin, HbA, with the heme groups spacefilled.
spacefilled deoxyHbA heme on off	spacefilled oxyHbA heme on off

2. Spacefilled images of HbA with the 2,3-BPG binding pocket located at the top between the two b-subunits (dark and light red). Note this pocket is deeper and more open in the deoxyHb conformer.
with dexoxyHbA spacefilled subunits	with oxyHbA spacefilled subunits
dexoxyHbA size in Å units	oxyHbA size in Å units

Color Scheme

3. Spacefilled images of HbA looking down between the two a-subunits (dark and light blue) opposite the BPG pocket.
the deoxyHbA a-a interface	the oxyHbA a-a interface

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