| WATER METABOLISM AND SODIUM METABOLISM ARE INTERRELATED
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The actions of aldosterone and vasopressin comprise a control system that directs the handling of both water and sodium by the kidney
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| Normally, despite large variations in fluid intake, plasma osmolality is maintained within narrow limits (280-295 mmol/kg H2O). Vasopressin contributes to the control of plasma osmolality by regulating water metabolism. It responds to both osmotic and volume signals. On the one hand its secretion, and thirst, are stimulated by signals from osmoreceptors which respond to even minute (about 1%) increase in plasma osmolality. On the other, vasopressin release is stimulated by a decrease (more than 10%) in circulating volume which triggers receptors sensitive to pressure.
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