Āris Kaksis Riga Stradin's University assistant professor

B Course description and Objectives «Medical chemistry experimental research»:
2025. RSU
Using the ChemScape Chime tools and related original aplications for
Research with ISIS Draw applications ISISDraw , RasWin (RasMol) RasMol .
Students can get the knowledge and skills about:
elemental (C, O,H, N,P,Fe,S, Na+,Ca²⁺) composition and its recognition in the displayed geometry symetry of molecules :
wire-frame, stick, stick&ball, spacefill as well as superimposing the color scheme CPK
into symbolic presentation of chemical elements on the depicted structures of molecules and
1°, 2°, 3° and 4° structures of polymere molecules .

Research 1. Task for investigation of enzyme Aquaporīns 0:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Aquaporīna 0:
Nobel prise 2003 Peter Agre Illlinoise University: http://aris.gusc.lv/ChemFiles/Aquaporins/Illinois06/Illinois06.pdf
Aquaporines 0 related selected publications:
1.Overview:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1-11.pdf
2.Channel size:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP-1-4-MZchannel1J4N.pdf
3.Aquaporin0 tetramer:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0channel1YMG-2B5F.pdf
4.Channel profile:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0-1-Z-GlpFchannel.pdf
5.Constriction SF NPA:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQPchannelProfil1RC2.pdf
6.Lipid,protein,pH interactions:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0lipids1YMG05.pdf
«Aquaporin0» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025
htdocsLoal http://aris.gusc.lv/ChemFiles/Aquaporins/AquaPorin1-0.htm
The mastering Aquaporin 0 structure fragment in research has a task obtain the skills,
which has the goal its employ for chemical studies and investigation of given
human Aquaporin 0 and tetramere integral cell membrane proteine channel for water molecules.

Research 2. Task for investigation of enzyme Aquaporin 1:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Aquaporīna 1:
Nobel prise 2003 Peter Agre Illlinoise University: http://aris.gusc.lv/ChemFiles/Aquaporins/Illinois06/Illinois06.pdf
Aquaporines 1 related selected publications:
1.Conductance velocity: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1-11Lat.pdf
2.Aquaporin1 tetramer profile: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1physiol1J4N10.pdf
3.Free energy barriers: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1physiology2010_1J4N.pdf
4.Constriction SF NPA: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQPchannelProfil1RC2.pdf
«Aquaporin1» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025
htdocsLoal http://aris.gusc.lv/ChemFiles/Aquaporins/AquaPorin1.htm

Research 3.Task for investigation of enzyme Alcohol DeHydrogenase ADH :
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums ADH:
B3 vitamins (nicotinic acid, niacin, nicotinic acid amide); NAD structure: nicotine adenine dinucleotide:
http://aris.gusc.lv/06Daugavpils/Research/NAD-NADH.pdf
B3 vitamīns (nikotīn skābe, niacins, nikotīnskābes amīds); NAD struktūra: nikotīn adenīn dinukleotīds:
http://aris.gusc.lv/06Daugavpils/Research/NAD-NADHLat.pdf
«Alcohol DeHydrogenase ADH» Aris Kaksis, RSU “Medical Biochemistry Data Base” ©, 2025
http://aris.gusc.lv/ChemFiles/AlhoDeHydrogenase/NadDehydrogenase.htm

Research 4. Task for investigation of human enzyme Carbonic Anhydrase II:
ENZYME Carbonic Anhydrase HOMEOSTASIS BIOLOGIC BUFFER SYSTEM pH OF BLOOD 7.36 CApH7-36.pdf
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums cilvēka enzīms Karbo Anhidrāze II:
«Carbonic Anhydrase» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025
http://aris.gusc.lv/ChemFiles/CA/CAnhydraseII.htm
Protein Society Panel Discussion 2cba.pdb 01-JUN-92 (E.C.4.2.1.1) K.HAKANSSON,M.CARLSSON,L.A.SVENSSON,A.LILJAS
open Mage54PC/ProTour24/BCH259PE-3
http://aris.gusc.lv/ChemFiles/CA/CarbonicAnhy.kin

Research 6. Task for investigation of Human Serum Albumin HSA binding Fatty Acids lipoProtein
Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
Seruma albumīns - lipoprotīns:
«LipoProteine Human Serum Albumin» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2025:
«LipoProteine Human Serum Albumin binds Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025 http://aris.gusc.lv/ChemFiles/Albumin/cycox.html

Research 7. Task for investigation of Cyclo oxygenase COX and interaction of
Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin Proteins:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
ciklooksigenāzes COX olbaltumviela:
«Non-Enzymatic and Enzymatic Lipid peroxidation» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2025: http://aris.gusc.lv/06Daugavpils/Research/COXLab14.pdf
“Medical BiochemistryData Base”©,2017:http://aris.gusc.lv/06Daugavpils/Research/COXLab14Lat.pdf
«Cyclo oxygenase COX and interaction of Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025 http://aris.gusc.lv/ChemFiles/CycloOxigenase/cycox.html

Research 7a. Task for investigation of Cytochrome P450 CYP mono oxygenase
Proteins:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
citohroma P450 CYP mono oksigenāze olbaltumviela:
«Cytochrome P450 mono oxygenase» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2025: http://aris.gusc.lv/06Daugavpils/Research/COXLab14.pdf
“Medical BiochemistryData Base”©,2017:http://aris.gusc.lv/06Daugavpils/Research/COXLab14Lat.pdf
«Cytochrome P450 mono oxygenase»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025 http://aris.gusc.lv/ChemFiles/LiverErCYP2C51DT6-05/cycox.html

Research 8a. Task for investigation of Nuclear Receptors Androgene and
Human Mineralo corticoid Receptor (MR-NR3C2) Proteins:
Retīnskābes nukleāro receptoru studiju un izpētes praktiskā laboratorijas darba uzdevums :
Nuclear Receptor three families 2025: http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/NuclearReceptors.pdf
«Human Mineralo corticoid Receptor (MR-NR3C2) AS4_aldosterone.pdb» Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2017
Research 8a. Task Human Mineralo corticoid Receptor (MR-NR3C2) Proteins:
Retīnskābes nukleāro receptoru studiju un izpētes praktiskā laboratorijas darba uzdevums:

htdocsLoal «Androgen Nuclear Receptor Proteins»
Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2025
htdocsLoal http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/MineraloCorticoidReceptor/NR-A-G-P-R2AA2.htm

Research 9. «Human START proteins STARD1-13»
Task for investigatio of START Proteins:
START molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums:
Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2025
http://aris.gusc.lv/ChemFiles/START/START.htm

Research 10. Task for investigation of DNA methyl transferase Proteins:
DNA methyl transferase molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums:
«DNA methyl transferases Hha I, DNMT1, DNMT3» Aris Kaksis, Eric Martz RSU “Medical Biochemistry Data Base” © , 2025
http://aris.gusc.lv/NutritionBioChem/38DNSLabEng310311.pdf Aris Kaksis RSU 2025.
Āris Kaksis Rīgas Stradiņa universitāte 2011.
htdocsLoal http://aris.gusc.lv/ChemFiles/hhaiDNAmethylCtransferKeny/methmast.htm

Research 11. Task for investigation of enzyme CATALASE:
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums KATALĀZES:
«CATALASE» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2025
http://aris.gusc.lv/ChemFiles/catalaseKenyon/cat1.htm
The mastering CATALASE structure fragment in observation has a task obtain the working skills
with ISIS Draw applications RasMol , RasWin (RasMol) ISISDraw and ChemScape MDLi, ,
which has the goal its employ for chemical studies and investigation of given
bovine CATALASE and beef liver catalase liquid molecules.
Students can get the knowledge and skills about:
elemental (O, H) composition and its recognition in the displayed symetry of molecules :
wire-frame, stick, stick&ball, spacefill as well as superimposing the color scheme CPK
into symbolic presentation of chemical elements on the depicted structures of molecules.

Research 12. Task for investigation Biologic Oxidation Reduction :
Bioloģisko oksidēšanās-reducēšanās reakciju eksperimentālais pētījums:
«Biologic Oxidation and Reduction (Red–Ox) reactions Research» Aris Kaksis,
RSU “Medical Biochemistry Data Base” © , 2025 http://aris.gusc.lv/BioThermodynamics/OxRedBiologicalW.pdf
The mastering Red-Ox System (Half Reactions) Nernst's equation in research skills for electrode petntial:
E=Eo+0.0591log([[Fe+III(CN)₆]]/[[Fe+II(CN)₆]] )
E=Eo+0.0591log([Ox]/[Red] )