Āris Kaksis Riga Stradin's University assistant professor

B Course description and Objectives «Medical chemistry experimental research»:
http://aris.gusc.lv/2017MFArzBkurss.pdf; http://aris.gusc.lv/2018MFLatBkurss.pdf

Using the ChemScape Chime tools and related original aplications for
Research with ISIS Draw applications ISISDraw , RasWin (RasMol) RasMol .
Students can get the knowledge and skills about:
elemental (C, O,H, N,P,Fe,S, Na+,Ca²⁺) composition and its recognition in the displayed geometry symetry of molecules :
wire-frame, stick, stick&ball, spacefill as well as superimposing the color scheme CPK
into symbolic presentation of chemical elements on the depicted structures of molecules and
1°, 2°, 3° and 4° structures of polymere molecules .

Research 1. Task for investigation of enzyme Aquaporīns 0 Word document:research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Aquaporīna 0 Word dokuments: pētījums
Nobel prise 2003 Peter Agre Illlinoise University: http://aris.gusc.lv/ChemFiles/Aquaporins/Illinois06/Illinois06.pdf
Aquaporines 0 related selected publications:
1.Overview:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1-11.pdf
2.Channel size:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP-1-4-MZchannel1J4N.pdf
3.Aquaporin0 tetramer:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0channel1YMG-2B5F.pdf
4.Channel profile:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0-1-Z-GlpFchannel.pdf
5.Constriction SF NPA:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQPchannelProfil1RC2.pdf
6.Lipid,protein,pH interactions:http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP0lipids1YMG05.pdf
«Aquaporin0» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017
htdocsLoal http://aris.gusc.lv/ChemFiles/Aquaporins/AquaPorin1-0.htm
The mastering Aquaporin 0 structure fragment in research has a task obtain the skills,
which has the goal its employ for chemical studies and investigation of given
human Aquaporin 0 and tetramere integral cell membrane proteine channel for water molecules.

Research 2. Task for investigation of enzyme Aquaporin 1 Word document:research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Aquaporīna 1 Word dokuments pētījums
Nobel prise 2003 Peter Agre Illlinoise University: http://aris.gusc.lv/ChemFiles/Aquaporins/Illinois06/Illinois06.pdf
Aquaporines 1 related selected publications:
1.Conductance velocity: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1-11Lat.pdf
2.Aquaporin1 tetramer profile: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1physiol1J4N10.pdf
3.Free energy barriers: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQP1physiology2010_1J4N.pdf
4.Constriction SF NPA: http://aris.gusc.lv/ChemFiles/Aquaporins/WCPsAQPsIUBMBlife09/AQPchannelProfil1RC2.pdf
«Aquaporin1» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017
htdocsLoal http://aris.gusc.lv/ChemFiles/Aquaporins/AquaPorin1.htm

Research 3. Task for investigation of enzyme Alcohol DeHydrogenase ADH Word document:research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums ADH Word dokuments:pētījums
B3 vitamins (nicotinic acid, niacin, nicotinic acid amide); NAD structure: nicotine adenine dinucleotide:
http://aris.gusc.lv/06Daugavpils/Research/NAD-NADH.pdf
B3 vitamīns (nikotīn skābe, niacins, nikotīnskābes amīds); NAD struktūra: nikotīn adenīn dinukleotīds:
http://aris.gusc.lv/06Daugavpils/Research/NAD-NADHLat.pdf
«Alcohol DeHydrogenase ADH» Aris Kaksis, RSU “Medical Biochemistry Data Base” ©, 2017
http://aris.gusc.lv/ChemFiles/AlhoDeHydrogenase/NadDehydrogenase.htm

Research 4. Task for investigation of human enzyme Carbonic Anhydrase II Word document:research
ENZYME Carbonic Anhydrase HOMEOSTASIS BIOLOGIC BUFFER SYSTEM pH OF BLOOD 7.36 CApH7-36.pdf
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums cilvēka enzīms Karbo Anhidrāze II Word dokuments:pētījums
«Carbonic Anhydrase» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017
http://aris.gusc.lv/ChemFiles/CA/CAnhydraseII.htm
Protein Society Panel Discussion 2cba.pdb 01-JUN-92 (E.C.4.2.1.1) K.HAKANSSON,M.CARLSSON,L.A.SVENSSON,A.LILJAS
open Mage54PC/ProTour24/BCH259PE-3
http://aris.gusc.lv/ChemFiles/CA/CarbonicAnhy.kin

Research 6. Task for investigation of Human Serum Albumin HSA binding Fatty Acids lipoProtein
Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin Word document: research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
Seruma albumīns - lipoprotīns Word dokuments:pētījums
«LipoProteine Human Serum Albumin» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2017:
«LipoProteine Human Serum Albumin binds Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017 http://aris.gusc.lv/ChemFiles/Albumin/cycox.html

Research 7. Task for investigation of Cyclo oxygenase COX and interaction of
Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin Proteins Word document: research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
ciklooksigenāzes COXolbaltumvielu Word dokuments: pētījums
«Non-Enzymatic and Enzymatic Lipid peroxidation» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2017: http://aris.gusc.lv/06Daugavpils/Research/COXLab14.pdf
“Medical BiochemistryData Base”©,2017:http://aris.gusc.lv/06Daugavpils/Research/COXLab14Lat.pdf
«Cyclo oxygenase COX and interaction of Aspirin, Tylenol, Warfarin, Ibuprofen, Flourbiprofen, IndoMethacin»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017 http://aris.gusc.lv/ChemFiles/CycloOxigenase/cycox.html

Research 7a. Task for investigation of Cytochrome P450 CYP mono oxygenase
Proteins Word document: research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums
citohroma P450 CYP mono oksigenāze olbaltumviela Word dokuments: pētījums
«Cytochrome P450 mono oxygenase» Aris Kaksis, RSU
“Medical Biochemistry Data Base” ©, 2017: http://aris.gusc.lv/06Daugavpils/Research/COXLab14.pdf
“Medical BiochemistryData Base”©,2017:http://aris.gusc.lv/06Daugavpils/Research/COXLab14Lat.pdf
«Cytochrome P450 mono oxygenase»
Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017 http://aris.gusc.lv/ChemFiles/LiverErCYP2C51DT6-05/cycox.html

Research 8a. Task for investigation of Nuclear Receptors Androgene and
Human Mineralo corticoid Receptor (MR-NR3C2) Proteins Word document: research
Retīnskābes nukleāro receptoru studiju un izpētes praktiskā laboratorijas darba uzdevums
Word dokuments: pētījums
Nuclear Receptor three families 2017: http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/NuclearReceptors.pdf
«Human Mineralo corticoid Receptor (MR-NR3C2) AS4_aldosterone.pdb» Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2017
Research 8a. Task Human Mineralo corticoid Receptor (MR-NR3C2) Proteins Word document: research
Retīnskābes nukleāro receptoru studiju un izpētes praktiskā laboratorijas darba uzdevums
Word dokuments: pētījums
htdocsLoal http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/AndrogenReceptor/Androgen1.htm
«Androgen Nuclear Receptor Proteins»
Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2017
htdocsLoal http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/MineraloCorticoidReceptor/NR-A-G-P-R2AA2.htm

Research 9. «Human START proteins STARD1-13»
Task for investigatio of START nProteins Word document:research
START molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Word dokuments:pētījums
Aris Kaksis, RSU “Medical Biochemistry Data Base”©,2017
http://aris.gusc.lv/ChemFiles/START/START.htm

Research 10. Task for investigation of DNA methyl transferase Proteins Word document:research
DNA methyl transferase molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums Word dokuments:pētījums
«DNA methyl transferases Hha I, DNMT1, DNMT3» Aris Kaksis, Eric Martz RSU “Medical Biochemistry Data Base” © , 2017
http://aris.gusc.lv/NutritionBioChem/38DNSLabEng310311.pdf Aris Kaksis RSU 2017.
Āris Kaksis Rīgas Stradiņa universitāte 2011.
htdocsLoal http://aris.gusc.lv/ChemFiles/hhaiDNAmethylCtransferKeny/methmast.htm

Research 11. Task for investigation of enzyme CATALASE Word document:research
Molekulu studiju un izpētes praktiskā laboratorijas darba uzdevums KATALĀZES Word dokuments: pētījums
«CATALASE» Aris Kaksis, RSU “Medical Biochemistry Data Base” © , 2017
http://aris.gusc.lv/ChemFiles/catalaseKenyon/cat1.htm
The mastering CATALASE structure fragment in observation has a task obtain the working skills
with ISIS Draw applications RasMol , RasWin (RasMol) ISISDraw and ChemScape MDLi, ,
which has the goal its employ for chemical studies and investigation of given
bovine CATALASE and beef liver catalase liquid molecules.
Students can get the knowledge and skills about:
elemental (O, H) composition and its recognition in the displayed symetry of molecules :
wire-frame, stick, stick&ball, spacefill as well as superimposing the color scheme CPK
into symbolic presentation of chemical elements on the depicted structures of molecules.

Research 12. Task for investigation Biologic Oxidation Reduction Research Word document:research
Bioloģisko oksidēšanās-reducēšanās reakciju eksperimentālais pētījums Word dokuments:pētījums
«Biologic Oxidation and Reduction (Red–Ox) reactions Research» Aris Kaksis,
RSU “Medical Biochemistry Data Base” © , 2017 http://aris.gusc.lv/BioThermodynamics/OxRedBiologicalW.pdf
The mastering Red-Ox System (Half Reactions) Nernst's equation in research skills for electrode petntial:
E=Eo+0.0591log([[Fe+III(CN)₆]]/[[Fe+II(CN)₆]] )
E=Eo+0.0591log([Ox]/[Red] )