|hnRNP A1 Structure for Molecular Biology Show the: The two RNA-binding domains of hnRNP A1.|
The human hnRNP A1 protein is involved in the packaging, splicing, and transport of mRNA. The two RNA-binding domains are shown using the Cartoon display. RBD1 (residues 1-87) is colored light blue; RBD2 (residues 105-180) is colored violet; and the linker segment between domains is blue. The N- and C-termini are labeled. (cf. Fig. 2 of Shamoo et al.).
Each domain has the RNP consensus sequence that is also found in more than 250 other protein sequences. This homologous sequence is proposed to fold into the conserved babbab fold seen here. (Color the structure by Group; click on the RBD1 button; and trace the chain from the blue N-terminus to the green C-terminus of domain 1. The same topology is seen in domain 2, colored from green to red.)