|Show the: U1A Protein Structure for Molecular Biology The U1A-RNA Complex. |
The U1A-RNA Complex is involved in the splicing of mRNA. The RNA-binding domain (RBD1) is shown using the Cartoon display. The protein is colored by Structure and the RNA is colored Shapely, with white backbone. The N- and C-termini are labeled. (cf. Fig. 4 of Oubridge et al.).
The domain has the RNP consensus sequence that is also found in more than 250 other protein sequences. This homologous sequence is proposed to fold into the conserved babbab fold seen here. (Color the structure by Group; click on the "Protein, only" button; and trace the chain from the blue N-terminus to the red C-terminus of the protein.)
|The sidechains of Tyr13, Phe56, and Asp102 are shown as Spacefill with CPK coloring. The bases of Cyt 10, Ade 11, and Cyt 12 are shown as Spacefill with Shapely coloring. Tyr13 stacks atop Cyt 10 and forms a perpendicular "aromatic-aromatic" interaction with Phe56. Phe56 and Asp102 sandwich the bases of Ade 11 and Cyt 12 in a four-member stack. (cf. Fig. 5e of Oubridge et al.)
Use the buttons to the right of the image to show only portions of the structure; then use the Chime menu to display or color the molecule. The rotate buttons act on the entire structure. Remove the distance monitors with a second click.