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Lecture Schedule

The dates shown correspond to the Tuesday and Thursday class meetings at 3:00 pm in Mellon Institute, Room 448.
Assigned readings in Cantor & Schimmel are indicated by   [Chapter, pages].
Problem set due-dates and exam dates are shown on the course calendar.

Go to lecture topics for This Week

Week of Jan. 13 & 15.

Week of Jan. 20 & 22.

  • Vibrational Spectroscopy.   [8, pp. 466-472]
  • Linear & Circular Dichroism.   [7, pp. 368-370; 8, pp. 409-433]
    A clear overview of Circular Dichroism Spectroscopy at the Lawrence Livermore National Laboratory. Concise explanations and references to the current literature on protein applications.

Week of Jan. 27 & 29.

  • Fluorescence - Quenching & Energy Transfer.   [8, pp. 433-454]
  • Fluorescence - Depolarization.   [8, pp. 454-465]
    The pages at Molecular Probes Inc. describe the properties and applications of a wide variety of fluorescent probes. Their Other Sites page also provides many links to academic and commercial sites where fluorescence spectroscopy is being used.

Week of Feb. 3 & 5.

  • Protein Structure & Thermodynamics.   [2, pp. 41-53; pp. 86-116] & [5, pp. 253-298]
  • Helix-Coil Transitions.   [20, pp. 1041-1053]
    Tutorial on Protein Architecture using Chime-generated images of Protein G.
    Take a Protein Structure Quiz based on the crystal structure of the B1 domain of protein G.

Week of Feb. 10 & 12.

  • Protein Folding Mechanisms - Calorimetry.   [21, pp. 1075-1088]
  • Protein Folding Mechanisms - Kinetics.   [21, pp. 1088-1098; 7, pp. 907-922]
    Some Student displays of protein G from Problem Set #3.

Week of Feb. 17 & 19.

  • Nucleic Acid Structures.   [3, pp. 155-204]
    One-page (Chime) overviews of:
        B-DNA Structure.
        A-RNA Structure.
    A Chime-based tutorial on tRNA Structure.
    Some Student displays of tRNAPhe from Problem Set #4.
  • Nucleic Acid Energetics.   [6, pp. 311-337]
    Compare (or check) your answers to the Problem Set #4 questions on DNA and RNA energetics with those that can be computed at the Turner Lab using the efn server.

Week of Feb. 24 & 26.

  • X-ray Diffraction - Scattering from Lattices.   [13, pp. 687-753]
  • X-ray Diffraction - Determination of Phase/Refinement.   [13, pp. 754-785]
    A tour of X-ray Crystallography at Lawrence Livermore National Laboratory.
    Choose the "Crystallography 101" button for general topics on the technique.
    Also look at Kevin Cowtan's Book of Fourier. How to "transform a duck"!
    An annotated Example of a PDB file from the online RasMol manual.

Week of Mar. 3 & 5.


Week of Mar. 10 & 12.

Week of Mar. 17 & 19.

  • NMR Spectroscopy - Multidimensional NMR II.
  • NMR Spectroscopy - Chemical Exchange & Protein Dynamics.

Week of Mar. 24 & 26.

  • Spring Break.
  • Spring Break.

Week of Mar. 31 & Apr 2.

  • NMR Spectroscopy - Protein Structure Refinement.
    NMR Structures Demonstration from class lecture.
  • Electron Spin Resonance.   [9, pp. 525-534]

Week of Apr. 7 & 9.

Week of Apr. 14 & 16.

  • Multiple Equilibria.
  • Cooperativity & Allosterism.   [17, pp. 939-971]

Week of Apr. 21 & 23.

  • Surface Plasmon Resonance Spectrometry.
    SPRWeb has a tutorial and links to other SPR topics.
  • Protein-Protein Binding Mechanisms.

Week of Apr. 28 & 30.

Week of May 5 & 7 (Final Exam Week).

  • EXAM II.   Thurs. May 7; 1:00 pm; Room MI355.


Last modified: April 29, 1998.