Chemistry Biochemistry for medical and
pharmacy Students
Tentative
Lecture schedule "Biochemistry of Medicinals I" lecturescheduleM.html, lecturescheduleM.doc, lecturescheduleM_MacWord5 .
Part 2 – Nucleic Acids Phar
6151
Instructor: Dr. Natalia
Tretyakova, Ph.D.
«hyperlink
"mailto:Trety001@umn.edu" »
6-3432
PDB
reference correction and design Dr.chem.,
Ph.D. Aris Kaksis, Associate Prof. e-mail:
ariska@latnet.lv
11-05
Introduction. DNA
structure DNAstructureNTM.html, DNAstructureNTM.doc, DNAstructureNTM_MacWord5 , DNAstructureNTM2.html, DNAstructureNTM2.doc, DNAstructureNTM2_MacWord5 , Double helix, A,
B, Z
–form of DNA. Biophysical properties
of DNA NTbiochemChap1nM.html, NTbiochemChap1nM.doc, NTbiochemChap1nM_MacWord5,
NTbiochemChap2M.html, NTbiochemChap2M.doc, NTbiochemChap2M_MacWord5, NTbiochemChap3M.html, NTbiochemChap3M.doc, NTbiochemChap3M_MacWord5, NTbiochemChap4M.html, NTbiochemChap4M.doc, NTbiochemChap4M_MacWord5,
.
11-07 DNA topology DNAstructureNTM2.html,
DNAstructureNTM2.doc,
DNAstructureNTM2_MacWord5.
Supercoiling. Enzymes
that change DNA: endonucleases, exonucleases, topoisomerases.
11-09 DNA replication. Polymerization
reaction DNAsynthesis1AM.html,
DNAsynthesis1AM.doc,
DNAsynthesis1AM_MacWord5.
E. Coli Pol I
11-12 DNA replication
(continued) DNAsynthesis1BM.html,
DNAsynthesis1BM.doc,
DNAsynthesis1BM_MacWord5.
. Initiation,
elongation, and termination DNAsynthesis1CM.html,
DNAsynthesis1CM.doc,
DNAsynthesis1CM_MacWord5, DNAsynthesis2M.html,
DNAsynthesis2M.doc,
DNAsynthesis2M_MacWord5.
11-13 DNA specific
replication machinery at the telomere ends
DNAsynthesis2telomerM0.html, DNAsynthesis2telomerM0.doc, DNAsynthesis2telomerM0_MacWord5.
.
DNA
sequence specific binding Proteins: Oncogene Transcription Factors,
Template Primer, Repressors, Opressors, Operators, Engraileed
Homeodomaines, Telomer binding Recombinase - Resolvase
DNAsynthesis2telomerM2.html, DNAsynthesis2telomerM2.doc, DNAsynthesis2telomerM2_MacWord5.
.
DNA
sequence specific binding Proteins: Catabolite Gene activator, TATA
Box protein, U turn binding, SRY binding, Estrogen O Receptor,
RiboNuclease, Restriction EndoNucleases
DNAsynthesis2telomerM3.html, DNAsynthesis2telomerM3.doc, DNAsynthesis2telomerM3_MacWord5.
.
11-14 DNA repair. Mutations
and cancer DNAdamage1M.html,
DNAdamage1M.doc,
DNAdamage1M_MacWord5.
, DNAdamage2M.html,
DNAdamage2M.doc,
DNAdamage2M_MacWord5 .
11-16 Transcription lecture11-30M.html, lecture11-30M.doc, lecture11-30M_MacWord5, lecture12-03M.html, lecture12-03M.doc, lecture12-03M_MacWord5, ..
11-19 RNA structure. NTbiochemChap5M.html, NTbiochemChap5M.doc, NTbiochemChap5M_MacWord5, RNA
synthesis in prokaryotes. RNA Pol. I.
11-21 RNA synthesis in
eukaryotes. .
NTRNAsynthesisM.html, NTRNAsynthesisM.doc, NTRNAsynthesisM_MacWord5, . Transcription
factors.
NTbiochemChap7aM.html, NTbiochemChap7aM.doc, NTbiochemChap7aM_MacWord5,
11-23 No class
NTcontrolGeneexp12M.html, NTcontrolGeneexp12M.doc, NTcontrolGeneexp12M_MacWord5, NTcontrolGeneExpM.html, NTcontrolGeneExpM.doc, NTcontrolGeneExpM_MacWord5,
11-26 Post-transcriptional modifications
in eukaryotes. Review of DNA
11-28 Exam I. Nucleic acids. DNA structure and
synthesis. Transcription.
mRNA.
11-30 RNA splicing.
NTRNAsplicingM.html, NTRNAsplicingM.doc, NTRNAsplicingM_MacWord5, .
12-03 Translation. Genetic code.
tRNA.
NTbiochemChap6aM.html, NTbiochemChap6aM.doc, NTbiochemChap6aM_MacWord5,
12-05 tRNA
activation
.
problemset1M.html, problemset1M.doc, problemset1M_MacWord5, .
12-07 Codon-anticodon
interactions
12-10 Protein synthesis – translation NTProteinSynRibosomM.html, NTProteinSynRibosomM.doc, NTProteinSynRibosomM_MacWord5, .
12-12 Protein synthesis – translocation.
Drugs inhibiting protein synthesis
12-14 Review of tRNA,
Protein synthesis. Gene Expresion
Regulation
12-17 Exam II. tRNA .
Protein synthesis. StudyQuestionsCh1M.html, ptudyQuestionsCh1M.doc, StudyQuestionsCh1M_MacWord5, .